| Gene Symbol |
PLXNB2
|
| Entrez Gene |
23654
|
| Alt Symbol |
MM1, Nbla00445, PLEXB2, dJ402G11.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
plexin B2
|
| Other Description |
plexin-B2
|
| Swissprots |
Q9BSU7 O15031 Q7KZU3 A6QRH0
|
| Accessions |
CCF76956 O15031 AB002313 BAA21571 AB075511 BAE45757 AK025415 AK025701 AK056543 AK074932 AK123131 AK126394 BC000221 BC004542 AAH04542 BC110366 AAI10367 BC127770 AAI27771 BC148225 BC148280 BC172440 AAI72440 BT006887 AAP35533 CN388620 S76730 AAB33781 XM_005261909 XP_005261966 XM_005261910 XP_005261967 XM_005261911 XP_005261968 XM_006724413 XP_006724476 XM_011530682 XP_011528984 XM_011530683 XP_011528985 XM_011530684 XP_011528986 NM_012401 NP_036533
|
| Function |
Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound- healing assays (in vitro) (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:12533544}; Single-pass type I membrane protein {ECO:0000269|PubMed:12533544}.
|
| Top Pathways |
Axon guidance
|