PLXNB2
| Gene Symbol | PLXNB2 |
|---|---|
| Entrez Gene | 23654 |
| Alt Symbol | MM1, Nbla00445, PLEXB2, dJ402G11.3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | plexin B2 |
| Other Description | plexin-B2 |
| Swissprots | Q9BSU7 O15031 Q7KZU3 A6QRH0 |
| Accessions | CCF76956 O15031 AB002313 BAA21571 AB075511 BAE45757 AK025415 AK025701 AK056543 AK074932 AK123131 AK126394 BC000221 BC004542 AAH04542 BC110366 AAI10367 BC127770 AAI27771 BC148225 BC148280 BC172440 AAI72440 BT006887 AAP35533 CN388620 S76730 AAB33781 XM_005261909 XP_005261966 XM_005261910 XP_005261967 XM_005261911 XP_005261968 XM_006724413 XP_006724476 XM_011530682 XP_011528984 XM_011530683 XP_011528985 XM_011530684 XP_011528986 NM_012401 NP_036533 |
| Function | Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound- healing assays (in vitro) (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:12533544}; Single-pass type I membrane protein {ECO:0000269|PubMed:12533544}. |
| Top Pathways | Axon guidance |
plexin-B2 CRISPR/Cas9 KO Plasmid (h) - sc-403754 from Santa Cruz Biotechnology
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plexin-B2 HDR Plasmid (h) - sc-403754-HDR from Santa Cruz Biotechnology
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plexin-B2 Double Nickase Plasmid (h) - sc-403754-NIC from Santa Cruz Biotechnology
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plexin-B2 Double Nickase Plasmid (h2) - sc-403754-NIC-2 from Santa Cruz Biotechnology
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plexin-B2 CRISPR Activation Plasmid (h) - sc-403754-ACT from Santa Cruz Biotechnology
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plexin-B2 CRISPR Activation Plasmid (h2) - sc-403754-ACT-2 from Santa Cruz Biotechnology
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plexin-B2 Lentiviral Activation Particles (h) - sc-403754-LAC from Santa Cruz Biotechnology
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plexin-B2 Lentiviral Activation Particles (h2) - sc-403754-LAC-2 from Santa Cruz Biotechnology
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plexin-B2 siRNA (h) - sc-45422 from Santa Cruz Biotechnology
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plexin-B2 shRNA Plasmid (h) - sc-45422-SH from Santa Cruz Biotechnology
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plexin-B2 shRNA (h) Lentiviral Particles - sc-45422-V from Santa Cruz Biotechnology
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Plexin B2 RNAi - H00023654-R01 from Novus Biologicals
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Plexin B2 RNAi - H00023654-R02 from Novus Biologicals
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Plexin B2 RNAi - H00023654-R03 from Novus Biologicals
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MISSION® esiRNA - EHU061411 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17014 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17014 from Sigma-Aldrich
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PLXNB2 siRNA (Human) - CRH8425 from Cohesion Biosciences
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shRNA set against Human PLXNB2 (NM_012401.3) - SHH378248 from Creative biogene
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Human PLXNB2 siRNA - orb268927 from Biorbyt
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PLXNB2 shRNA Plasmid (Human) - CHH8425 from Cohesion Biosciences
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PLXNB2 miRNA 3'UTR clone - MiUTR3H-06700 from Creative biogene
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