| Gene Symbol |
PGAM5
|
| Entrez Gene |
192111
|
| Alt Symbol |
BXLBV68
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphoglycerate mutase family member 5
|
| Other Description |
Bcl-XL-binding protein v68|serine/threonine-protein phosphatase PGAM5, mitochondrial
|
| Swissprots |
A9LN06 C9IZY7 Q96JB0 Q96HS1
|
| Accessions |
EAW54825 EAW54826 EAW54827 Q96HS1 AF357523 AAK60627 AK097688 BC008196 AAH08196 BC047906 CA307621 CR995429 D25830 DR155760 EU249757 ABX39494 NM_001170543 NP_001164014 NM_001170544 NP_001164015 NM_138575 NP_612642
|
| Function |
Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore. {ECO:0000269|PubMed:18387606, ECO:0000269|PubMed:19590015, ECO:0000269|PubMed:22265414}.
|
| Subcellular Location |
Mitochondrion outer membrane {ECO:0000269|PubMed:18387606}; Single-pass membrane protein {ECO:0000269|PubMed:18387606}. Note=Isoform 2 overexpression results in the formation of disconnected punctuate mitochondria distributed throughout the cytoplasm. Isoform 1 overexpression results in the clustering of mitochondria around the nucleus.
|
| Top Pathways |
TNF signaling pathway
|