PGAM5

Gene Symbol PGAM5
Entrez Gene 192111
Alt Symbol BXLBV68
Species Human
Gene Type protein-coding
Description phosphoglycerate mutase family member 5
Other Description Bcl-XL-binding protein v68|serine/threonine-protein phosphatase PGAM5, mitochondrial
Swissprots A9LN06 C9IZY7 Q96JB0 Q96HS1
Accessions EAW54825 EAW54826 EAW54827 Q96HS1 AF357523 AAK60627 AK097688 BC008196 AAH08196 BC047906 CA307621 CR995429 D25830 DR155760 EU249757 ABX39494 NM_001170543 NP_001164014 NM_001170544 NP_001164015 NM_138575 NP_612642
Function Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore. {ECO:0000269|PubMed:18387606, ECO:0000269|PubMed:19590015, ECO:0000269|PubMed:22265414}.
Subcellular Location Mitochondrion outer membrane {ECO:0000269|PubMed:18387606}; Single-pass membrane protein {ECO:0000269|PubMed:18387606}. Note=Isoform 2 overexpression results in the formation of disconnected punctuate mitochondria distributed throughout the cytoplasm. Isoform 1 overexpression results in the clustering of mitochondria around the nucleus.
Top Pathways TNF signaling pathway

PGAM5 CRISPR/Cas9 KO Plasmid (h) - sc-401300 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PGAM5 HDR Plasmid (h) - sc-401300-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PGAM5 Double Nickase Plasmid (h) - sc-401300-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PGAM5 Double Nickase Plasmid (h2) - sc-401300-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PGAM5 CRISPR Activation Plasmid (h) - sc-401300-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PGAM5 CRISPR Activation Plasmid (h2) - sc-401300-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PGAM5 Lentiviral Activation Particles (h) - sc-401300-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PGAM5 Lentiviral Activation Particles (h2) - sc-401300-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PGAM5 siRNA (h) - sc-96246 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PGAM5 shRNA Plasmid (h) - sc-96246-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PGAM5 shRNA (h) Lentiviral Particles - sc-96246-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU145401 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16671 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16671 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02633 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02633

PGAM5 siRNA (Human) - CRJ6152 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PGAM5 (NM_138575.3) - SHH374108 from Creative biogene

Category siRNA
Species Reactivities Human

PGAM5 shRNA Plasmid (Human) - CHJ6152 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PGAM5 miRNA 3'UTR clone - MiUTR4H-TG06623 from Creative biogene

Species Reactivities Human
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