PGAM5

Gene Symbol	PGAM5
Entrez Gene	192111
Alt Symbol	BXLBV68
Species	Human
Gene Type	protein-coding
Description	phosphoglycerate mutase family member 5
Other Description	Bcl-XL-binding protein v68|serine/threonine-protein phosphatase PGAM5, mitochondrial
Swissprots	A9LN06 C9IZY7 Q96JB0 Q96HS1
Accessions	EAW54825 EAW54826 EAW54827 Q96HS1 AF357523 AAK60627 AK097688 BC008196 AAH08196 BC047906 CA307621 CR995429 D25830 DR155760 EU249757 ABX39494 NM_001170543 NP_001164014 NM_001170544 NP_001164015 NM_138575 NP_612642
Function	Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore. {ECO:0000269|PubMed:18387606, ECO:0000269|PubMed:19590015, ECO:0000269|PubMed:22265414}.
Subcellular Location	Mitochondrion outer membrane {ECO:0000269|PubMed:18387606}; Single-pass membrane protein {ECO:0000269|PubMed:18387606}. Note=Isoform 2 overexpression results in the formation of disconnected punctuate mitochondria distributed throughout the cytoplasm. Isoform 1 overexpression results in the clustering of mitochondria around the nucleus.
Top Pathways	TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PGAM5-Antibody-C-term-Blocking-Peptide - BP17900b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Serine/threonine-protein phosphatase PGAM5, mitochondrial(PGAM5) - CSB-YP839338HU CSB-EP839338HU CSB-BP839338HU CSB-MP839338HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PGAM5 (transcript variant 1) - TP329840 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PGAM5 Recombinant Protein Antigen - NBP1-92258PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PGAM5 Recombinant Protein Antigen - NBP1-92257PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PGAM5 Peptide, Human - M34GP11641H from Creative Peptides Category Peptide Source Synthetic. Species Human

PGAM5 Recombinant Protein Antigen - NBP2-52947PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Source E. coli Species Human

Serine/threonine-protein phosphatase PGAM5, mitochondrial (PGAM5), Recombinant Protein - MBS1372393 from MyBioSource Category Protein Prices $1,045.00, $1,045.00, $1,275.00, $1,275.00, $1,625.00, $1,625.00, $2,085.00, $2,085.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PGAM5 fusion protein - Ag28195 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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