CDK3
| Gene Symbol | CDK3 |
|---|---|
| Entrez Gene | 1018 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | cyclin-dependent kinase 3 |
| Other Description | cell division protein kinase 3 |
| Swissprots | Q00526 |
| Accessions | AAV40830 EAW89353 EAW89354 EAW89355 Q00526 AU146328 BC128406 BC160074 AAI60074 BU784937 BX098771 DB455174 X66357 CAA47001 NM_001258 NP_001249 |
| Function | Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0- G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1- independent manner. {ECO:0000269|PubMed:15084261, ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:8846921}. |
| Tissue Specificity | Expressed in cancer cell lines and glioblastoma tissue. {ECO:0000269|PubMed:18794154}. |
Cdk3 CRISPR/Cas9 KO Plasmid (h) - sc-400846 from Santa Cruz Biotechnology
|
||||||||
Cdk3 HDR Plasmid (h) - sc-400846-HDR from Santa Cruz Biotechnology
|
||||||||
Cdk3 Double Nickase Plasmid (h) - sc-400846-NIC from Santa Cruz Biotechnology
|
||||||||
Cdk3 Double Nickase Plasmid (h2) - sc-400846-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Cdk3 CRISPR Activation Plasmid (h) - sc-400846-ACT from Santa Cruz Biotechnology
|
||||||||
Cdk3 CRISPR Activation Plasmid (h2) - sc-400846-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Cdk3 Lentiviral Activation Particles (h) - sc-400846-LAC from Santa Cruz Biotechnology
|
||||||||
Cdk3 Lentiviral Activation Particles (h2) - sc-400846-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Cdk3 siRNA (h) - sc-37578 from Santa Cruz Biotechnology
|
||||||||
Cdk3 shRNA Plasmid (h) - sc-37578-SH from Santa Cruz Biotechnology
|
||||||||
Cdk3 shRNA (h) Lentiviral Particles - sc-37578-V from Santa Cruz Biotechnology
|
||||||||
Cdk3 siRNA (h2) - sc-156140 from Santa Cruz Biotechnology
|
||||||||
Cdk3 shRNA Plasmid (h2) - sc-156140-SH from Santa Cruz Biotechnology
|
||||||||
Cdk3 shRNA (h2) Lentiviral Particles - sc-156140-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU147011 from Sigma-Aldrich
|
||||||||
MISSION® esiRNA - EHU220861 from Sigma-Aldrich
|
||||||||
MISSION® siRNA - SIHK0348 from Sigma-Aldrich
|
||||||||
MISSION® siRNA - SIHK0349 from Sigma-Aldrich
|
||||||||
MISSION® siRNA - SIHK0347 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN5849 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5849 from Sigma-Aldrich
|
||||||||
CDK3 siRNA (Human) - CRH0731 from Cohesion Biosciences
|
||||||||
Cdk3 RNAi - H00001018-R02 from Novus Biologicals
|
||||||||
CDK3 - MBS8202319 from MyBioSource
|
||||||||
shRNA set against Human CDK3 (NM_001258.2) - SHH260605 from Creative biogene
|