Gene Symbol | DIS3L |
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Entrez Gene | 115752 |
Alt Symbol | DIS3L1 |
Species | Human |
Gene Type | protein-coding |
Description | DIS3 like exosome 3'-5' exoribonuclease |
Other Description | DIS3 mitotic control homolog-like|DIS3-like exonuclease 1 |
Swissprots | Q96CM7 Q8N1N8 Q8TF46 Q8WTU9 |
Accessions | CCQ43824 EAW77758 EAW77759 EAW77760 EAW77761 Q8TF46 AB075835 BAB85541 AF147431 AK095407 BAC04542 AK123202 AK295392 BAG58346 BC014124 AAH14124 BC022089 AAH22089 BG722405 BM833083 BP219623 DQ893470 ABM84396 EU176766 ABW03567 NM_001143688 NP_001137160 XM_005254144 XP_005254201 XM_005254145 XP_005254202 XM_005254146 XP_005254203 XM_005254147 XP_005254204 NM_133375 NP_588616 |
Function | Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. {ECO:0000269|PubMed:20531386, ECO:0000269|PubMed:20531389}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:20531386, ECO:0000269|PubMed:20531389}. |
Top Pathways | RNA degradation |
DIS3L (E-12) - sc-398739 from Santa Cruz Biotechnology
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DIS3L (D-15) - sc-242581 from Santa Cruz Biotechnology
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DIS3L (H-110) - sc-368891 from Santa Cruz Biotechnology
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DIS3L (W-18) - sc-242579 from Santa Cruz Biotechnology
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Anti-DIS3L antibody - ab89042 from Abcam
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Anti-DIS3L Antibody (aa195-224, AP) - LS-C256105 from LifeSpan Bioscience
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Anti-DIS3L Antibody (aa195-224, Azide-free, HRP) - LS-C256109 from LifeSpan Bioscience
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Anti-DIS3L Antibody (aa195-224) - LS-C167411 from LifeSpan Bioscience
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Anti-DIS3L Antibody (aa195-224, PE) - LS-C256110 from LifeSpan Bioscience
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Anti-DIS3L Antibody (aa202-232) - LS-C320841 from LifeSpan Bioscience
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Anti-DIS3L Antibody - LS-C308996 from LifeSpan Bioscience
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Anti-DIS3L Antibody (aa195-224, APC) - LS-C256106 from LifeSpan Bioscience
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Anti-DIS3L Antibody (aa195-224, Biotin) - LS-C256107 from LifeSpan Bioscience
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Anti-DIS3L Antibody (aa195-224, FITC) - LS-C256108 from LifeSpan Bioscience
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DIS3L Antibody - H00115752-B01P from Novus Biologicals
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DIS3L Antibody - NBP1-81941 from Novus Biologicals
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DIS3L Polyclonal Antibody - bs-9052R from Bioss
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Anti-MGC4562 antibody produced in mouse - SAB1400782 from Sigma-Aldrich
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Anti-DIS3L antibody produced in rabbit - HPA041805 from Sigma-Aldrich
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ANTI-DI3L1 (N-TERMINAL) antibody produced in rabbit - SAB1306324 from Sigma-Aldrich
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DIS3L Antibody - N-terminal region (OAAB03025) - OAAB03025 from Aviva Systems Biology
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DI3L1-Antibody-N-term - AP5614a from Abgent, a WuXi AppTec company
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Anti -DI3L1, NT (DIS3L, DIS3L1, KIAA1955, DIS3-like exonuclease 1) - 034639 from USBiological Life Science
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Anti -DI3L1, NT (DIS3L, DIS3L1, KIAA1955, DIS3-like exonuclease 1) (AP) - 034639-AP from USBiological Life Science
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Anti -DI3L1, NT (DIS3L, DIS3L1, KIAA1955, DIS3-like exonuclease 1) (APC) - 034639-APC from USBiological Life Science
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