| Gene Symbol |
DIS3L
|
| Entrez Gene |
115752
|
| Alt Symbol |
DIS3L1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DIS3 like exosome 3'-5' exoribonuclease
|
| Other Description |
DIS3 mitotic control homolog-like|DIS3-like exonuclease 1
|
| Swissprots |
Q96CM7 Q8N1N8 Q8TF46 Q8WTU9
|
| Accessions |
CCQ43824 EAW77758 EAW77759 EAW77760 EAW77761 Q8TF46 AB075835 BAB85541 AF147431 AK095407 BAC04542 AK123202 AK295392 BAG58346 BC014124 AAH14124 BC022089 AAH22089 BG722405 BM833083 BP219623 DQ893470 ABM84396 EU176766 ABW03567 NM_001143688 NP_001137160 XM_005254144 XP_005254201 XM_005254145 XP_005254202 XM_005254146 XP_005254203 XM_005254147 XP_005254204 NM_133375 NP_588616
|
| Function |
Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. {ECO:0000269|PubMed:20531386, ECO:0000269|PubMed:20531389}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:20531386, ECO:0000269|PubMed:20531389}.
|
| Top Pathways |
RNA degradation
|
![Western Blot: DIS3L Overexpression Lysate (Adult Normal) [NBP2-05706] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DIS3L.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10464_DIS3L%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05706-img0001.jpg)