DIS3L

Gene Symbol DIS3L
Entrez Gene 115752
Alt Symbol DIS3L1
Species Human
Gene Type protein-coding
Description DIS3 like exosome 3'-5' exoribonuclease
Other Description DIS3 mitotic control homolog-like|DIS3-like exonuclease 1
Swissprots Q96CM7 Q8N1N8 Q8TF46 Q8WTU9
Accessions CCQ43824 EAW77758 EAW77759 EAW77760 EAW77761 Q8TF46 AB075835 BAB85541 AF147431 AK095407 BAC04542 AK123202 AK295392 BAG58346 BC014124 AAH14124 BC022089 AAH22089 BG722405 BM833083 BP219623 DQ893470 ABM84396 EU176766 ABW03567 NM_001143688 NP_001137160 XM_005254144 XP_005254201 XM_005254145 XP_005254202 XM_005254146 XP_005254203 XM_005254147 XP_005254204 NM_133375 NP_588616
Function Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. {ECO:0000269|PubMed:20531386, ECO:0000269|PubMed:20531389}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:20531386, ECO:0000269|PubMed:20531389}.
Top Pathways RNA degradation

DIS3L CRISPR/Cas9 KO Plasmid (h) - sc-407861 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIS3L HDR Plasmid (h) - sc-407861-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIS3L Double Nickase Plasmid (h) - sc-407861-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIS3L Double Nickase Plasmid (h2) - sc-407861-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIS3L CRISPR Activation Plasmid (h) - sc-407861-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIS3L CRISPR Activation Plasmid (h2) - sc-407861-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIS3L Lentiviral Activation Particles (h) - sc-407861-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIS3L Lentiviral Activation Particles (h2) - sc-407861-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIS3L siRNA (h) - sc-89907 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DIS3L shRNA Plasmid (h) - sc-89907-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DIS3L shRNA (h) Lentiviral Particles - sc-89907-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DIS3L RNAi - H00115752-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU085661 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7250 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7250 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04317 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04317

DIS3L siRNA (Human) - CRJ4465 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DIS3L - MBS8211596 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DIS3L (NM_133375.3) - SHH278249 from Creative biogene

Category siRNA
Species Reactivities Human

Human DIS3L siRNA - orb274966 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DIS3L shRNA Plasmid (Human) - CHJ4465 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DIS3L miRNA 3'UTR clone - MiUTR3H-13163 from Creative biogene

Species Reactivities Human

DIS3L miRNA 3'UTR clone - MiUTR3H-13164 from Creative biogene

Species Reactivities Human
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