RAP1A

Gene Symbol RAP1A
Entrez Gene 5906
Alt Symbol C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21
Species Human
Gene Type protein-coding
Description RAP1A, member of RAS oncogene family
Other Description GTP-binding protein smg p21A|Ras-related protein Krev-1|ras-related protein Rap-1A
Swissprots P62834 P10113
Accessions CAA00804 EAW56503 P62834 AB051846 BAB61868 AB451235 BAG70049 AB451360 BAG70174 AF493912 AAM12626 AK023457 AK094737 AK293044 BAF85733 BC014086 AAH14086 BG743233 BI460853 BQ220294 BT019666 AAV38472 BU150941 BU167449 BU189979 BX473371 CA446565 CD108761 DA102623 DB312010 EU831467 ACE87154 EU831554 ACE86473 M22995 AAA36150 X12533 CAA31051 XM_011541883 XP_011540185 XR_946724 NM_001010935 NP_001010935 NM_001291896 NP_001278825 NM_002884 NP_002875
Function Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. {ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:21840392}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:11359771}; Lipid-anchor {ECO:0000269|PubMed:11359771}. Cytoplasm {ECO:0000269|PubMed:11359771}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11359771}. Cell junction {ECO:0000250}. Early endosome {ECO:0000250}. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region. {ECO:0000250}.
Top Pathways Rap1 signaling pathway, Focal adhesion, cAMP signaling pathway, Pancreatic secretion, Chemokine signaling pathway

RAP1A-Over-expression-Lysate - LY13593a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag RAP1A (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the RAP1A gene

RAP1A 293 Cell Lysate - 409890 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

RAP1A 293 Cell Lysate - 408902 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

RAP1A Overexpression Lysate (Native) - NBL1-15146 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: RAP1A Overexpression Lysate (Adult Normal) [NBL1-15146] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RAP1A.

RAP1A Overexpression Lysate (Native) - NBL1-15145 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: RAP1A Overexpression Lysate (Adult Normal) [NBL1-15145] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RAP1A.

RAP1A Over-expression Lysate Product - GWB-F33D28 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

RAP1A Over-expression Lysate Product - GWB-A9CC7F from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

Panoply™ Human RAP1A Knockdown Stable Cell Line - CSC-DC012959 from Creative biogene

Category Cell Line
Species Human
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