RAP1A

Gene Symbol	RAP1A
Entrez Gene	5906
Alt Symbol	C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21
Species	Human
Gene Type	protein-coding
Description	RAP1A, member of RAS oncogene family
Other Description	GTP-binding protein smg p21A|Ras-related protein Krev-1|ras-related protein Rap-1A
Swissprots	P62834 P10113
Accessions	CAA00804 EAW56503 P62834 AB051846 BAB61868 AB451235 BAG70049 AB451360 BAG70174 AF493912 AAM12626 AK023457 AK094737 AK293044 BAF85733 BC014086 AAH14086 BG743233 BI460853 BQ220294 BT019666 AAV38472 BU150941 BU167449 BU189979 BX473371 CA446565 CD108761 DA102623 DB312010 EU831467 ACE87154 EU831554 ACE86473 M22995 AAA36150 X12533 CAA31051 XM_011541883 XP_011540185 XR_946724 NM_001010935 NP_001010935 NM_001291896 NP_001278825 NM_002884 NP_002875
Function	Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. {ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:21840392}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:11359771}; Lipid-anchor {ECO:0000269|PubMed:11359771}. Cytoplasm {ECO:0000269|PubMed:11359771}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11359771}. Cell junction {ECO:0000250}. Early endosome {ECO:0000250}. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region. {ECO:0000250}.
Top Pathways	Rap1 signaling pathway, Focal adhesion, cAMP signaling pathway, Pancreatic secretion, Chemokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rap 1 siRNA (h) - sc-36384 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Rap 1 shRNA Plasmid (h) - sc-36384-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Rap 1 shRNA (h) Lentiviral Particles - sc-36384-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Rap 1A CRISPR/Cas9 KO Plasmid (h) - sc-400572 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Rap 1A HDR Plasmid (h) - sc-400572-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rap 1A Double Nickase Plasmid (h) - sc-400572-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rap 1A Double Nickase Plasmid (h2) - sc-400572-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rap 1A CRISPR Activation Plasmid (h) - sc-400572-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Rap 1A CRISPR Activation Plasmid (h2) - sc-400572-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Rap 1A Lentiviral Activation Particles (h) - sc-400572-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rap 1A Lentiviral Activation Particles (h2) - sc-400572-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rap 1A siRNA (h) - sc-41852 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Rap 1A shRNA Plasmid (h) - sc-41852-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Rap 1A shRNA (h) Lentiviral Particles - sc-41852-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RAP1A RNAi - H00005906-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

RAP1A RNAi - H00005906-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU092751 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17945 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17945 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07838 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr07838

RAP1A siRNA (Human) - CRH3993 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RAP1A - MBS8200545 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human RAP1A (NM_002884.2) - SHH389564 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human RAP1A(NM_002884.2) - SHR164014 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human RAP1A(NM_001010935.1) - SHR164426 from Creative biogene Category siRNA Species Reactivities Human

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