RAP1A

Gene Symbol RAP1A
Entrez Gene 5906
Alt Symbol C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21
Species Human
Gene Type protein-coding
Description RAP1A, member of RAS oncogene family
Other Description GTP-binding protein smg p21A|Ras-related protein Krev-1|ras-related protein Rap-1A
Swissprots P62834 P10113
Accessions CAA00804 EAW56503 P62834 AB051846 BAB61868 AB451235 BAG70049 AB451360 BAG70174 AF493912 AAM12626 AK023457 AK094737 AK293044 BAF85733 BC014086 AAH14086 BG743233 BI460853 BQ220294 BT019666 AAV38472 BU150941 BU167449 BU189979 BX473371 CA446565 CD108761 DA102623 DB312010 EU831467 ACE87154 EU831554 ACE86473 M22995 AAA36150 X12533 CAA31051 XM_011541883 XP_011540185 XR_946724 NM_001010935 NP_001010935 NM_001291896 NP_001278825 NM_002884 NP_002875
Function Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. {ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:21840392}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:11359771}; Lipid-anchor {ECO:0000269|PubMed:11359771}. Cytoplasm {ECO:0000269|PubMed:11359771}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11359771}. Cell junction {ECO:0000250}. Early endosome {ECO:0000250}. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region. {ECO:0000250}.
Top Pathways Rap1 signaling pathway, Focal adhesion, cAMP signaling pathway, Pancreatic secretion, Chemokine signaling pathway

Human-RAP1A-cDNA-Clone - DC03754 from Abgent, a WuXi AppTec company

Prices $248.40
Sizes 10 µg
Species Human
Accession BC014086

RAP1A - MBS1275798 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC014086

Human RAP1A cDNA clone(NM_001010935.1) - CDFH015888 from Creative Biomart

Species Human
Accession NM_001010935.1

Human RAP1A cDNA clone(NM_002884.2) - CDFH015889 from Creative Biomart

Species Human
Accession NM_002884.2

Human RAP1A ORF Clone(NM_002884.2) - CDCL173266 from Creative Biomart

Species Human
Accession NM_002884.2

Human RAP1A ORF Clone(NM_002884.2) - CDCR284318 from Creative Biomart

Species Human
Accession NM_002884.2

Human RAP1A ORF Clone(NM_002884.2) - CDCR284319 from Creative Biomart

Species Human
Accession NM_002884.2

Human RAP1A ORF Clone(NM_001010935.1) - CDCR340919 from Creative Biomart

Species Human
Accession NM_001010935.1

Human RAP1A ORF Clone(NM_001010935.1) - CDCR340920 from Creative Biomart

Species Human
Accession NM_001010935.1

Human RAP1A ORF Clone(NM_001010935.1) - CDCR340921 from Creative Biomart

Species Human
Accession NM_001010935.1

Human RAP1A ORF Clone(NM_002884.2) - CDCR284318 from Creative biogene

Species Human

Human RAP1A ORF Clone(NM_001010935.1) - CDCR340919 from Creative biogene

Species Human

Human RAP1A ORF Clone (BC014086) - CDCS406448 from Creative biogene

Species Human
Accession A8KAH9

Human RAP1A cDNA Clone(NM_001010935.1) - CDFH015888 from Creative biogene

Species Human

Human RAP1A cDNA Clone(NM_002884.2) - CDFH015889 from Creative biogene

Species Human
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