RAP1A

Gene Symbol	RAP1A
Entrez Gene	5906
Alt Symbol	C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21
Species	Human
Gene Type	protein-coding
Description	RAP1A, member of RAS oncogene family
Other Description	GTP-binding protein smg p21A|Ras-related protein Krev-1|ras-related protein Rap-1A
Swissprots	P62834 P10113
Accessions	CAA00804 EAW56503 P62834 AB051846 BAB61868 AB451235 BAG70049 AB451360 BAG70174 AF493912 AAM12626 AK023457 AK094737 AK293044 BAF85733 BC014086 AAH14086 BG743233 BI460853 BQ220294 BT019666 AAV38472 BU150941 BU167449 BU189979 BX473371 CA446565 CD108761 DA102623 DB312010 EU831467 ACE87154 EU831554 ACE86473 M22995 AAA36150 X12533 CAA31051 XM_011541883 XP_011540185 XR_946724 NM_001010935 NP_001010935 NM_001291896 NP_001278825 NM_002884 NP_002875
Function	Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. {ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:21840392}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:11359771}; Lipid-anchor {ECO:0000269|PubMed:11359771}. Cytoplasm {ECO:0000269|PubMed:11359771}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11359771}. Cell junction {ECO:0000250}. Early endosome {ECO:0000250}. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region. {ECO:0000250}.
Top Pathways	Rap1 signaling pathway, Focal adhesion, cAMP signaling pathway, Pancreatic secretion, Chemokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RAP1A full length protein - ab97904 from Abcam Category Protein Source E. coli Species Human

Human RAP1A G12V full length protein - ab90611 from Abcam Category Protein Source E. coli Species Human

RAP1A Antibody Blocking Peptide - LS-E2061 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAP1A Antibody Blocking Peptide - LS-E23130 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAP1A Recombinant Protein - H00005906-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human RAP1A Protein - NBP1-45263 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E. coli Species Human

RAP1A-Antibody-C-term-Blocking-peptide - BP12949b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RAP1A Protein (OPPA02354) - OPPA02354 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human RAP1A protein - orb81304 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

RAP1A peptide - orb73161 from Biorbyt Category Peptide Prices $323.00 Sizes 500 µg

RAP1A Blocking Peptide - abx063885 from Abbexa Category Peptide Species Human, Monkey

RAP1A - AR00161PU-N from Acris Antibodies Category Protein Prices $380.00 Sizes 25 µg Species Human

RAP1A (1-181, His-tag) - AR09535PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

RAP1A (1-181, His-tag) - AR09535PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

RAP1A - H00005906-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RAP1A - H00005906-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RAP1A, 1-181aa, Human, His tag, E.coli - 01-1858-1A from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

RAP1A fusion protein - Ag9463 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

RAP1A fusion protein - Ag9488 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

RAP1A Human - PRPS-855 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human RAP1A, Member RAS Oncogene Family Protein - BP002356-PRO-848 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

RAP1A, 1-181aa, Recombinant Protein - GWB-P1440J from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 50 μg, 250 μg Source E.coli Species Human

RAP1A Human Protein - GWB-BSP601 from Genway Biotech Category Protein Prices $75.00, $165.00, $6,190.00 Sizes 2 μg, 10 μg, 1000 μg Source Escherichia Coli. Species Human

Recombinant Human RAP1A, His-tagged - RAP1A-2584H from Creative Biomart Category Protein Source E.coli.

Recombinant Human RAP1A, His-tagged - RAP1A-30502TH from Creative Biomart Category Protein Source E. coli Species Human

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