RAP1A

Gene Symbol	RAP1A
Entrez Gene	5906
Alt Symbol	C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21
Species	Human
Gene Type	protein-coding
Description	RAP1A, member of RAS oncogene family
Other Description	GTP-binding protein smg p21A|Ras-related protein Krev-1|ras-related protein Rap-1A
Swissprots	P62834 P10113
Accessions	CAA00804 EAW56503 P62834 AB051846 BAB61868 AB451235 BAG70049 AB451360 BAG70174 AF493912 AAM12626 AK023457 AK094737 AK293044 BAF85733 BC014086 AAH14086 BG743233 BI460853 BQ220294 BT019666 AAV38472 BU150941 BU167449 BU189979 BX473371 CA446565 CD108761 DA102623 DB312010 EU831467 ACE87154 EU831554 ACE86473 M22995 AAA36150 X12533 CAA31051 XM_011541883 XP_011540185 XR_946724 NM_001010935 NP_001010935 NM_001291896 NP_001278825 NM_002884 NP_002875
Function	Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. {ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:21840392}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:11359771}; Lipid-anchor {ECO:0000269|PubMed:11359771}. Cytoplasm {ECO:0000269|PubMed:11359771}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11359771}. Cell junction {ECO:0000250}. Early endosome {ECO:0000250}. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region. {ECO:0000250}.
Top Pathways	Rap1 signaling pathway, Focal adhesion, cAMP signaling pathway, Pancreatic secretion, Chemokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rap1A/Rap1B (26B4) Rabbit mAb - 2399 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone 26B4

Rap1A/Rap1B Antibody - 4938 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Rap 1 (K-17) - sc-34258 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Rap 1 (E-6) - sc-398755 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Rap 1 (Q-13) - sc-34257 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Rap 1 (121) - sc-65 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Rap 1A (C-10) - sc-373968 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Rap 1A (C-17) - sc-1482 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-RAP1A + RAP1B antibody [EPR14814] - ab187659 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR14814

Anti-RAP1A + RAP1B antibody [EP879Y] - ab75871 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP879Y

Anti-RAP1A + RAP1B antibody [EPR14815(B)] - ab181858 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR14815(B)

Anti-RAP1A antibody - ab96223 from Abcam Prices $376.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-RAP1A antibody - ab55741 from Abcam Prices $378.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-RAP1A G12V antibody [EP878] - ab124963 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP878

Anti-RAP1A Antibody (aa160-174) - LS-C17606 from LifeSpan Bioscience Prices $345.00 Sizes 25 µg Host Rabbit Clonality Polyclonal

Anti-RAP1A Antibody (aa142-170, AP) - LS-C217133 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RAP1A Antibody (aa142-170, APC) - LS-C217134 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RAP1A Antibody (aa142-170, Biotin) - LS-C217135 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RAP1A Antibody (aa142-170, FITC) - LS-C217136 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RAP1A Antibody (aa142-170, Azide-free, HRP) - LS-C217137 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RAP1A Antibody (aa142-170, PE) - LS-C217140 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RAP1A Antibody (aa141-170) - LS-C324524 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RAP1A Antibody (Internal, clone EP878) - LS-C138643 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP878

Anti-RAP1A Antibody (clone 3E1) - LS-C198059 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3E1

Anti-RAP1A Antibody (C-Terminus) - LS-C170400 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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