PRKD1

Gene Symbol	PRKD1
Entrez Gene	5587
Alt Symbol	PKC-MU, PKCM, PKD, PRKCM
Species	Human
Gene Type	protein-coding
Description	protein kinase D1
Other Description	nPKC-D1|nPKC-mu|protein kinase C mu type|protein kinase C, mu|protein kinase D|serine/threonine-protein kinase D1
Swissprots	B2RAF6 A6NL64 Q15139
Accessions	ABE96833 EAW65970 EAW65971 Q15139 AK314170 BAG36853 BC160015 AAI60015 BX645735 CN412379 X75756 CAA53384 XM_005267859 XP_005267916 XM_011536964 XP_011535266 XM_011536965 XP_011535267 XR_943493 NM_002742 NP_002733
Function	Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterot
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:18076381}. Cell membrane {ECO:0000269|PubMed:18076381}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Note=Translocation to the cell membrane is required for kinase activation.
Top Pathways	Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HTScan® PKD/PKCμ Kinase Assay Kit - 7412 from Cell Signaling Technology Category Assay Kit

Mouse/Human/Rat Phospho-PRKD1 / PKC Mu (Ser205) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1306 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate

Mouse/Human/Rat Phospho-PRKD1 / PKC Mu (Tyr463) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1307 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate

Mouse/Human/Rat PRKD1 / PKC Mu ELISA Kit (Cell-Based ELISA) - LS-F2255 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

Protein Kinase D1, PKD1, Human, ELISA Kit - E-EL-H1185 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Protein Kinase D1, PKD1, Mouse, ELISA Kit - E-EL-M0980 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protein Kinase D1, PKD1, Rat, ELISA Kit - E-EL-R0816 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protein Kinase D1, PKD1, Rabbit, ELISA Kit - E-EL-RB0886 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protein Kinase D1, PKD1, Chicken, ELISA Kit - E-EL-Ch2042 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Protein Kinase D1, PKD1, Porcine, ELISA Kit - E-EL-P0255 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protein Kinase D1, PKD1, Guinea Pig, ELISA Kit - E-EL-GP0908 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Protein Kinase D1, PKD1, Monkey, ELISA Kit - E-EL-MK1001 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

PKD1/2/3 Colorimetric Cell-Based ELISA Kit - CB5569 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

PKD1/PKC mu Colorimetric Cell-Based ELISA Kit - CB5570 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

PKD1/2/3 (Phospho-Ser738+Ser742) Colorimetric Cell-Based ELISA Kit - CBP1278 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

PKD1/PKC mu (Phospho-Ser205) Colorimetric Cell-Based ELISA Kit - CBP1311 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

PKD1/PKC mu (Phospho-Tyr463) Colorimetric Cell-Based ELISA Kit - CBP1312 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Protein Kinase D1, ELISA Kit - MBS723778 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase D1, ELISA Kit - MBS731007 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase D1, ELISA Kit - MBS724098 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase D1, ELISA Kit - MBS754339 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase D1 - MBS753064 from MyBioSource Category ELISA Kit Prices $470.00, $675.00 Sizes 48 strip wells, 96 strip wells

Protein Kinase D1, ELISA Kit - MBS747467 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase D1, ELISA Kit - MBS755147 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

Protein Kinase D1, ELISA Kit - MBS750285 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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