PRKD1
| Gene Symbol | PRKD1 |
|---|---|
| Entrez Gene | 5587 |
| Alt Symbol | PKC-MU, PKCM, PKD, PRKCM |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein kinase D1 |
| Other Description | nPKC-D1|nPKC-mu|protein kinase C mu type|protein kinase C, mu|protein kinase D|serine/threonine-protein kinase D1 |
| Swissprots | B2RAF6 A6NL64 Q15139 |
| Accessions | ABE96833 EAW65970 EAW65971 Q15139 AK314170 BAG36853 BC160015 AAI60015 BX645735 CN412379 X75756 CAA53384 XM_005267859 XP_005267916 XM_011536964 XP_011535266 XM_011536965 XP_011535267 XR_943493 NM_002742 NP_002733 |
| Function | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterot |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:18076381}. Cell membrane {ECO:0000269|PubMed:18076381}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Note=Translocation to the cell membrane is required for kinase activation. |
| Top Pathways | Rap1 signaling pathway |
PKC μ CRISPR/Cas9 KO Plasmid (h) - sc-401070 from Santa Cruz Biotechnology
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PKC μ HDR Plasmid (h) - sc-401070-HDR from Santa Cruz Biotechnology
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PKC μ Double Nickase Plasmid (h) - sc-401070-NIC from Santa Cruz Biotechnology
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PKC μ Double Nickase Plasmid (h2) - sc-401070-NIC-2 from Santa Cruz Biotechnology
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PKC μ CRISPR Activation Plasmid (h) - sc-401070-ACT from Santa Cruz Biotechnology
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PKC μ CRISPR Activation Plasmid (h2) - sc-401070-ACT-2 from Santa Cruz Biotechnology
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PKC μ Lentiviral Activation Particles (h) - sc-401070-LAC from Santa Cruz Biotechnology
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PKC μ Lentiviral Activation Particles (h2) - sc-401070-LAC-2 from Santa Cruz Biotechnology
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PKC μ siRNA (h) - sc-36245 from Santa Cruz Biotechnology
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PKC μ shRNA Plasmid (h) - sc-36245-SH from Santa Cruz Biotechnology
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PKC μ shRNA (h) Lentiviral Particles - sc-36245-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU054741 from Sigma-Aldrich
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MISSION® siRNA - SIHK1845 from Sigma-Aldrich
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MISSION® siRNA - SIHK1847 from Sigma-Aldrich
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MISSION® siRNA - SIHK1846 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1555 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1555 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06264 from Sigma-Aldrich
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PRKD1 siRNA (Human) - CRH3757 from Cohesion Biosciences
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PKC mu RNAi - H00005587-R04 from Novus Biologicals
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shRNA set against Human PRKD1 (NM_002742.2) - SHH382912 from Creative biogene
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Human PRKD1 siRNA - orb264259 from Biorbyt
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PRKD1 shRNA Plasmid (Human) - CHH3757 from Cohesion Biosciences
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PRKD1 miRNA 3'UTR clone - MiUTR1H-08283 from Creative biogene
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