PRKD1

Gene Symbol	PRKD1
Entrez Gene	5587
Alt Symbol	PKC-MU, PKCM, PKD, PRKCM
Species	Human
Gene Type	protein-coding
Description	protein kinase D1
Other Description	nPKC-D1|nPKC-mu|protein kinase C mu type|protein kinase C, mu|protein kinase D|serine/threonine-protein kinase D1
Swissprots	B2RAF6 A6NL64 Q15139
Accessions	ABE96833 EAW65970 EAW65971 Q15139 AK314170 BAG36853 BC160015 AAI60015 BX645735 CN412379 X75756 CAA53384 XM_005267859 XP_005267916 XM_011536964 XP_011535266 XM_011536965 XP_011535267 XR_943493 NM_002742 NP_002733
Function	Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterot
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:18076381}. Cell membrane {ECO:0000269|PubMed:18076381}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Note=Translocation to the cell membrane is required for kinase activation.
Top Pathways	Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PRKD1 overexpression lysate - LY419136 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

PRKD1 293 Cell Lysate - 408955 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

PKC mu Overexpression Lysate (Native) - NBL1-14779 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

PRKD1 Over-expression Lysate Product - GWB-4DDC55 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Panoply™ Human PRKD1 Knockdown Stable Cell Line - CSC-DC012407 from Creative biogene Category Cell Line Species Human

Search more