PRKD1

Gene Symbol	PRKD1
Entrez Gene	5587
Alt Symbol	PKC-MU, PKCM, PKD, PRKCM
Species	Human
Gene Type	protein-coding
Description	protein kinase D1
Other Description	nPKC-D1|nPKC-mu|protein kinase C mu type|protein kinase C, mu|protein kinase D|serine/threonine-protein kinase D1
Swissprots	B2RAF6 A6NL64 Q15139
Accessions	ABE96833 EAW65970 EAW65971 Q15139 AK314170 BAG36853 BC160015 AAI60015 BX645735 CN412379 X75756 CAA53384 XM_005267859 XP_005267916 XM_011536964 XP_011535266 XM_011536965 XP_011535267 XR_943493 NM_002742 NP_002733
Function	Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterot
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:18076381}. Cell membrane {ECO:0000269|PubMed:18076381}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Note=Translocation to the cell membrane is required for kinase activation.
Top Pathways	Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PKC mu full length protein - ab60873 from Abcam Category Protein Prices $239.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human PKC mu protein fragment - ab152632 from Abcam Category Protein Source Wheat germ Species Human

PRKD1 / PKD Mu Antibody Blocking Peptide - LS-E22419 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKD1 / PKD Mu Antibody Blocking Peptide - LS-E8613 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PKC mu Partial Recombinant Protein - H00005587-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PKC mu Protein - P4228 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Source Insect Species Human

PKC mu Recombinant Protein - P4761 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant PKC mu Protein - NBP1-99477 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

PKC mu Peptide - P2110 from Novus Biologicals Category Peptide Species Human

PKC-mu-Antibody-N-term-Blocking-Peptide - BP7023a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PKC mu (Active) recombinant protein - GTX65216 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

Polycystin 2 (Active) recombinant protein - GTX65204 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

PRKD1 - H00005587-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PRKD1 - H00005587-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PRKD1 - P4228 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

PRKD1 - P4761 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

Recombinant Human PRKD1 - PRKD1-29764TH from Creative Biomart Category Protein

Recombinant Human Protein Kinase D1, GST-tagged, Active - PRKD1-406H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Protein Kinase D1 (PKD1) - RPA508Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Protein Kinase D1 (PKD1) - RPA508Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

PKCµ Recombinant Human Protein, Active, 10 µg - 14-508 from EMD Millipore Category Protein Prices $401.00 Sizes 10 µg also available in 250 µg size --call for pricing and availability and reference catalog numbe Source Human PKCμ expressed in Sf21 cells Species Human

PKCµ Protein, active, 250 µg - 14-508M from EMD Millipore Category Protein Prices $2,543.00 Sizes 250 µg also available in 10 μg size . (cat#14-508) and in bulk (cat# 14-508-K) Source Human PKCμ expressed in Sf21 cells

PKC mu (pS910) Blocking Peptide - CBP1938 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

PKC mu Blocking Peptide - CBP3296 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Dog, Monkey

PKD1 (G459) Peptide - BS1581P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Search more