MAPKAPK2

Gene Symbol MAPKAPK2
Entrez Gene 9261
Alt Symbol MAPKAP-K2, MK-2, MK2
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase-activated protein kinase 2
Other Description MAP kinase-activated protein kinase 2|MAPK-activated protein kinase 2|MAPKAP kinase 2
Swissprots Q5SY30 Q8IYD6 Q5SY41 P49137
Accessions EAW93525 EAW93526 EAW93527 EAW93528 EAW93529 EAW93530 EAW93531 EAW93532 P49137 AK307499 BC036060 AAH36060 BC052584 AAH52584 BU621009 X75346 CAA53094 XM_005273353 XP_005273410 NM_004759 NP_004750 NM_032960 NP_116584
Function Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat- shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally
Subcellular Location Cytoplasm {ECO:0000269|PubMed:20932473}. Nucleus {ECO:0000269|PubMed:20932473}. Note=Phosphorylation and subsequent activation releases the autoinhibitory helix, resulting in the export from the nucleus into the cytoplasm.
Tissue Specificity Expressed in all tissues examined.
Top Pathways VEGF signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, Viral carcinogenesis

Mouse/Human/Rat MAPKAPK2 / MAPKAP Kinase 2 ELISA Kit (Cell-Based ELISA) - LS-F2128 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate

MAPKAPK2 (Human) IP-WB Antibody Pair - H00009261-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

MAPKAPK2 (Human) IP-WB Antibody Pair - H00009261-PW2 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

MAPKAPK2 (Human) IP-WB Antibody Pair - H00009261-PW3 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

Mitogen Activated Protein Kinase Activated Protein Kinase 2 (MAPKAPK2), ELISA Kit - MBS9313098 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1ng/ml.
Range 0.625 ng/ml - 20 ng/ml.

MAPKAPK2 Colorimetric Cell-Based ELISA Kit - CB5428 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

MAPKAPK2 (Phospho-Thr334) Colorimetric Cell-Based ELISA Kit - CBP1018 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

MAPKAPK2 (Phospho-Thr222) Colorimetric Cell-Based ELISA Kit - CBP1257 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

MAPKAPK2 (Phospho-Ser272) Colorimetric Cell-Based ELISA Kit - CBP1824 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

mitogen-activated protein kinase-activated protein kinase 2, ELISA Kit - MBS2602774 from MyBioSource

Category ELISA Kit
Prices $275.00, $420.00, $1,615.00, $2,880.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.06 ng/ml.
Range 20 ng/ml-0.312 ng/ml

MAPKAPK2 ELISA Kit - DEIA-XYA1168 from Creative Diagnostics

Category ELISA Kit

MAPKAPK2 (Phospho-Ser272) ELISA Kit - DEIA-XYA1169 from Creative Diagnostics

Category ELISA Kit

MAPKAPK2 (Phospho-Thr222) ELISA Kit - DEIA-XYA1170 from Creative Diagnostics

Category ELISA Kit

MAPKAPK2 (Phospho-Thr334) ELISA Kit - DEIA-XYA1171 from Creative Diagnostics

Category ELISA Kit

Human MAPKAPK2 ELISA Kit - E024760 from Biobool

Category ELISA Kit
Sensitivity 0.06 ng/ml.

Human MAP kinase-activated protein kinase 2 (MAPKAPK2) ELISA Kit - AE34274HU from ARP American Research Products

Category ELISA Kit
Prices $549.00
Sizes 96 t

MAP Kinase-Activated Protein Kinase 2 (MAPKAPK2), ELISA Kit - MBS9354273 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MAP Kinase-Activated Protein Kinase 2 (MAPKAPK2), ELISA Kit - MBS9344053 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase Activated Protein Kinase 2 (MAPKAPK2), ELISA Kit - MBS9362012 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase Activated Protein Kinase 2 (MAPKAPK2), ELISA Kit - MBS9353650 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MAP kinase-activated protein kinase 2 (MAPKAPK2), ELISA Kit - MBS2610308 from MyBioSource

Category ELISA Kit
Prices $300.00, $475.00, $1,825.00, $3,425.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MAP Kinase-Activated Protein Kinase 2 (MAPKAPK2), ELISA Kit - MBS9363143 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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