MAPKAPK2

Gene Symbol	MAPKAPK2
Entrez Gene	9261
Alt Symbol	MAPKAP-K2, MK-2, MK2
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase-activated protein kinase 2
Other Description	MAP kinase-activated protein kinase 2|MAPK-activated protein kinase 2|MAPKAP kinase 2
Swissprots	Q5SY30 Q8IYD6 Q5SY41 P49137
Accessions	EAW93525 EAW93526 EAW93527 EAW93528 EAW93529 EAW93530 EAW93531 EAW93532 P49137 AK307499 BC036060 AAH36060 BC052584 AAH52584 BU621009 X75346 CAA53094 XM_005273353 XP_005273410 NM_004759 NP_004750 NM_032960 NP_116584
Function	Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat- shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:20932473}. Nucleus {ECO:0000269|PubMed:20932473}. Note=Phosphorylation and subsequent activation releases the autoinhibitory helix, resulting in the export from the nucleus into the cytoplasm.
Tissue Specificity	Expressed in all tissues examined.
Top Pathways	VEGF signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MAPKAPK2 overexpression lysate - LY409844 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

MAPKAPK2 overexpression lysate - LY417772 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

MAPKAPK2 Overexpression Lysate (Native) - NBP2-10538 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human MAPKAPK2 Knockdown Stable Cell Line - CSC-DC009211 from Creative biogene Category Cell Line Species Human

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