MAPKAPK2
| Gene Symbol | MAPKAPK2 |
|---|---|
| Entrez Gene | 9261 |
| Alt Symbol | MAPKAP-K2, MK-2, MK2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | mitogen-activated protein kinase-activated protein kinase 2 |
| Other Description | MAP kinase-activated protein kinase 2|MAPK-activated protein kinase 2|MAPKAP kinase 2 |
| Swissprots | Q5SY30 Q8IYD6 Q5SY41 P49137 |
| Accessions | EAW93525 EAW93526 EAW93527 EAW93528 EAW93529 EAW93530 EAW93531 EAW93532 P49137 AK307499 BC036060 AAH36060 BC052584 AAH52584 BU621009 X75346 CAA53094 XM_005273353 XP_005273410 NM_004759 NP_004750 NM_032960 NP_116584 |
| Function | Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat- shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:20932473}. Nucleus {ECO:0000269|PubMed:20932473}. Note=Phosphorylation and subsequent activation releases the autoinhibitory helix, resulting in the export from the nucleus into the cytoplasm. |
| Tissue Specificity | Expressed in all tissues examined. |
| Top Pathways | VEGF signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, Viral carcinogenesis |
MAPKAPK-2 CRISPR/Cas9 KO Plasmid (h) - sc-401158 from Santa Cruz Biotechnology
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MAPKAPK-2 HDR Plasmid (h) - sc-401158-HDR from Santa Cruz Biotechnology
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MAPKAPK-2 Double Nickase Plasmid (h) - sc-401158-NIC from Santa Cruz Biotechnology
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MAPKAPK-2 Double Nickase Plasmid (h2) - sc-401158-NIC-2 from Santa Cruz Biotechnology
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MAPKAPK-2 CRISPR Activation Plasmid (h) - sc-401158-ACT from Santa Cruz Biotechnology
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MAPKAPK-2 CRISPR Activation Plasmid (h2) - sc-401158-ACT-2 from Santa Cruz Biotechnology
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MAPKAPK-2 Lentiviral Activation Particles (h) - sc-401158-LAC from Santa Cruz Biotechnology
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MAPKAPK-2 Lentiviral Activation Particles (h2) - sc-401158-LAC-2 from Santa Cruz Biotechnology
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MAPKAPK-2 siRNA (h) - sc-35855 from Santa Cruz Biotechnology
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MAPKAPK-2 shRNA Plasmid (h) - sc-35855-SH from Santa Cruz Biotechnology
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MAPKAPK-2 shRNA (h) Lentiviral Particles - sc-35855-V from Santa Cruz Biotechnology
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MAPKAPK2 RNAi - H00009261-R04 from Novus Biologicals
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MAPKAPK2 RNAi - H00009261-R03 from Novus Biologicals
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MISSION® esiRNA - EHU040821 from Sigma-Aldrich
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MISSION® siRNA - SIHK1229 from Sigma-Aldrich
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MISSION® siRNA - SIHK1228 from Sigma-Aldrich
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MISSION® siRNA - SIHK1225 from Sigma-Aldrich
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MISSION® siRNA - SIHK1230 from Sigma-Aldrich
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MISSION® siRNA - SIHK1227 from Sigma-Aldrich
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MISSION® siRNA - SIHK1226 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1546 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1546 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11126 from Sigma-Aldrich
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MAPKAPK2 siRNA (Human) - CRH6132 from Cohesion Biosciences
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shRNA set against Human MAPKAPK2 (NM_004759.4) - SHH338147 from Creative biogene
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