MAPKAPK2

Gene Symbol	MAPKAPK2
Entrez Gene	9261
Alt Symbol	MAPKAP-K2, MK-2, MK2
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase-activated protein kinase 2
Other Description	MAP kinase-activated protein kinase 2|MAPK-activated protein kinase 2|MAPKAP kinase 2
Swissprots	Q5SY30 Q8IYD6 Q5SY41 P49137
Accessions	EAW93525 EAW93526 EAW93527 EAW93528 EAW93529 EAW93530 EAW93531 EAW93532 P49137 AK307499 BC036060 AAH36060 BC052584 AAH52584 BU621009 X75346 CAA53094 XM_005273353 XP_005273410 NM_004759 NP_004750 NM_032960 NP_116584
Function	Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat- shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:20932473}. Nucleus {ECO:0000269|PubMed:20932473}. Note=Phosphorylation and subsequent activation releases the autoinhibitory helix, resulting in the export from the nucleus into the cytoplasm.
Tissue Specificity	Expressed in all tissues examined.
Top Pathways	VEGF signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active MAPKAP Kinase 2 protein fragment - ab60307 from Abcam Category Protein Prices $294.00, $1,845.00 Sizes 10 µg, 100 µg Source Baculovirus infected sf9 cells

Human MAPKAP Kinase 2 full length protein - ab79910 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human MAPKAP Kinase 2 full length protein - ab45154 from Abcam Category Protein Source E. coli Species Human

MAPKAPK2 / MAPKAP Kinase 2 Antibody Blocking Peptide - LS-E7283 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPKAPK2 / MAPKAP Kinase 2 Antibody Blocking Peptide - LS-E22072 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPKAPK2 / MAPKAP Kinase 2 Antibody Blocking Peptide - LS-E28035 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPKAPK2 / MAPKAP Kinase 2 Antibody Blocking Peptide - LS-E28036 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPKAPK2 Partial Recombinant Protein - H00009261-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MAPKAPK2 Recombinant Protein - H00009261-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MAPKAPK2 Recombinant Protein - P4220 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

Recombinant Human MAPKAPK2 Protein - P4716 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

Recombinant MAPKAPK2 Protein - NBP1-99493 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

MAPKAPK2 Peptide - P2401 from Novus Biologicals Category Peptide Species Human

MAPKAPK2 Peptide - P1343 from Novus Biologicals Category Peptide Species Human

Phospho-MAPKAPK2S272-Antibody-Blocking-peptide - BP3147a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

MAPKAPK2-Antibody-S272-Blocking-Peptide - BP7229d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAPKAPK-2 (Active) recombinant protein - GTX65303 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

Recombinant Human Active MAPKAPK2 (46-end), CF - 3705-KS-010 from R&D Systems Category Protein

MAPKAPK 2 Blocking Peptide - 33R-10447 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

MAPKAPK2 Blocking Peptide - 33R-10634 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

MAPKAPK2 Blocking Peptide - 33R-4542 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MAPKAPK2 protein - 30R-2851 from Fitzgerald Category Protein Prices $425.00 Sizes 5 µg Source Sf-9 insect cells Species Human

Human MAPKAPK2 Protein - abx068031 from Abbexa Category Protein Source E.coli Species Human

PRAK Peptide - AC21-2911-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PRAK Peptide - AC21-2912-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

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