MEOX1
| Gene Symbol | MEOX1 |
|---|---|
| Entrez Gene | 4222 |
| Alt Symbol | KFS2, MOX1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | mesenchyme homeobox 1 |
| Other Description | homeobox protein MOX-1 |
| Swissprots | A8MWF9 P50221 A8K524 Q15069 |
| Accessions | EAW51671 EAW51672 P50221 AK291139 BAF83828 AW410297 BC069474 AAH69474 BC069506 AAH69506 BE898972 BG677020 BQ003431 BQ028272 BX284090 EU446636 ABZ92165 U10492 AAA19983 U10493 AAA19984 XM_011524818 XP_011523120 NM_001040002 NP_001035091 NM_004527 NP_004518 NM_013999 NP_054705 |
| Function | Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. {ECO:0000250|UniProtKB:F1Q4R9, ECO:0000250|UniProtKB:P32442, ECO:0000269|PubMed:23290072, ECO:0000269|PubMed:24073994}. |
| Subcellular Location | Nucleus {ECO:0000250|UniProtKB:P32442}. Cytoplasm {ECO:0000250|UniProtKB:P32442}. Note=Localizes predominantly in the nucleus. {ECO:0000250|UniProtKB:P32442}. |
MOX-1 (A-15) - sc-10183 from Santa Cruz Biotechnology
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MOX-1 (3-RE14) - sc-134389 from Santa Cruz Biotechnology
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Anti-MOX1 antibody - ab105349 from Abcam
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Anti-MOX1 antibody - ab75895 from Abcam
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Anti-MOX1 antibody - ab23279 from Abcam
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Anti-MOX1 antibody - ab125712 from Abcam
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Anti-MOX1 antibody - ab194343 from Abcam
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Anti-MOX1 antibody - ab55715 from Abcam
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Anti-MOX1 antibody - ab55719 from Abcam
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Anti-MEOX1 Antibody (aa136-165) - LS-C164137 from LifeSpan Bioscience
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Anti-MEOX1 Antibody (clone 1D10) - LS-C139533 from LifeSpan Bioscience
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Anti-MEOX1 Antibody (clone 1D10) - LS-C139532 from LifeSpan Bioscience
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Anti-MEOX1 Antibody (aa136-165, AP) - LS-C263000 from LifeSpan Bioscience
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Anti-MEOX1 Antibody (aa136-165, Biotin) - LS-C263003 from LifeSpan Bioscience
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Anti-MEOX1 Antibody (aa136-165, FITC) - LS-C263004 from LifeSpan Bioscience
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Anti-MEOX1 Antibody (aa136-165, APC) - LS-C263002 from LifeSpan Bioscience
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Anti-MEOX1 Antibody (aa136-165, Azide-free, HRP) - LS-C263005 from LifeSpan Bioscience
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Anti-MEOX1 Antibody (aa136-165, PE) - LS-C263006 from LifeSpan Bioscience
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Anti-MEOX1 Antibody (N-Terminus, AP) - LS-C279657 from LifeSpan Bioscience
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Anti-MEOX1 Antibody (N-Terminus, Biotin) - LS-C279659 from LifeSpan Bioscience
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Anti-MEOX1 Antibody (N-Terminus, FITC) - LS-C279660 from LifeSpan Bioscience
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Anti-MEOX1 Antibody (N-Terminus, APC) - LS-C279658 from LifeSpan Bioscience
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Anti-MEOX1 Antibody (N-Terminus, Azide-free, HRP) - LS-C279661 from LifeSpan Bioscience
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Anti-MEOX1 Antibody (aa135-165) - LS-C322956 from LifeSpan Bioscience
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Anti-MEOX1 Antibody (N-Terminus, PE) - LS-C279662 from LifeSpan Bioscience
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