Gene Symbol | MEOX1 |
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Entrez Gene | 4222 |
Alt Symbol | KFS2, MOX1 |
Species | Human |
Gene Type | protein-coding |
Description | mesenchyme homeobox 1 |
Other Description | homeobox protein MOX-1 |
Swissprots | A8MWF9 P50221 A8K524 Q15069 |
Accessions | EAW51671 EAW51672 P50221 AK291139 BAF83828 AW410297 BC069474 AAH69474 BC069506 AAH69506 BE898972 BG677020 BQ003431 BQ028272 BX284090 EU446636 ABZ92165 U10492 AAA19983 U10493 AAA19984 XM_011524818 XP_011523120 NM_001040002 NP_001035091 NM_004527 NP_004518 NM_013999 NP_054705 |
Function | Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. {ECO:0000250|UniProtKB:F1Q4R9, ECO:0000250|UniProtKB:P32442, ECO:0000269|PubMed:23290072, ECO:0000269|PubMed:24073994}. |
Subcellular Location | Nucleus {ECO:0000250|UniProtKB:P32442}. Cytoplasm {ECO:0000250|UniProtKB:P32442}. Note=Localizes predominantly in the nucleus. {ECO:0000250|UniProtKB:P32442}. |
Human-MEOX1-cDNA-Clone - DC08756 from Abgent, a WuXi AppTec company
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MEOX1 - MBS1272864 from MyBioSource
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Human MEOX1 cDNA clone(NM_001040002.1) - CDFH011337 from Creative Biomart
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Human MEOX1 cDNA clone(NM_004527.3) - CDFH011338 from Creative Biomart
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Human MEOX1 cDNA clone(NM_013999.3) - CDFH011339 from Creative Biomart
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Human MEOX1 ORF Clone(NM_004527.3) - CDCR288274 from Creative Biomart
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Human MEOX1 ORF Clone(NM_004527.3) - CDCR288275 from Creative Biomart
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Human MEOX1 ORF Clone(NM_004527.3) - CDCR288276 from Creative Biomart
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Human MEOX1 ORF Clone(NM_013999.3) - CDCR296732 from Creative Biomart
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Human MEOX1 ORF Clone(NM_013999.3) - CDCR296733 from Creative Biomart
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Human MEOX1 ORF Clone(NM_001040002.1) - CDCR343968 from Creative Biomart
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Human MEOX1 ORF Clone(NM_001040002.1) - CDCR343969 from Creative Biomart
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Human MEOX1 ORF Clone(NM_001040002.1) - CDCR343970 from Creative Biomart
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Human MEOX1 ORF Clone(NM_004527.3) - CDCR288275 from Creative biogene
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Human MEOX1 ORF Clone(NM_013999.3) - CDCR296732 from Creative biogene
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Human MEOX1 ORF clone (NM_001040002.1) - CDCL131981 from Creative biogene
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Human MEOX1 ORF Clone (BC069474) - CDCS406998 from Creative biogene
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Human MEOX1 cDNA Clone(NM_001040002.1) - CDFH011337 from Creative biogene
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Human MEOX1 cDNA Clone(NM_004527.3) - CDFH011338 from Creative biogene
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Human MEOX1 cDNA Clone(NM_013999.3) - CDFH011339 from Creative biogene
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