MEOX1
| Gene Symbol | MEOX1 |
|---|---|
| Entrez Gene | 4222 |
| Alt Symbol | KFS2, MOX1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | mesenchyme homeobox 1 |
| Other Description | homeobox protein MOX-1 |
| Swissprots | A8MWF9 P50221 A8K524 Q15069 |
| Accessions | EAW51671 EAW51672 P50221 AK291139 BAF83828 AW410297 BC069474 AAH69474 BC069506 AAH69506 BE898972 BG677020 BQ003431 BQ028272 BX284090 EU446636 ABZ92165 U10492 AAA19983 U10493 AAA19984 XM_011524818 XP_011523120 NM_001040002 NP_001035091 NM_004527 NP_004518 NM_013999 NP_054705 |
| Function | Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. {ECO:0000250|UniProtKB:F1Q4R9, ECO:0000250|UniProtKB:P32442, ECO:0000269|PubMed:23290072, ECO:0000269|PubMed:24073994}. |
| Subcellular Location | Nucleus {ECO:0000250|UniProtKB:P32442}. Cytoplasm {ECO:0000250|UniProtKB:P32442}. Note=Localizes predominantly in the nucleus. {ECO:0000250|UniProtKB:P32442}. |
MOX-1 CRISPR/Cas9 KO Plasmid (h) - sc-408750 from Santa Cruz Biotechnology
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MOX-1 HDR Plasmid (h) - sc-408750-HDR from Santa Cruz Biotechnology
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MOX-1 Double Nickase Plasmid (h) - sc-408750-NIC from Santa Cruz Biotechnology
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MOX-1 Double Nickase Plasmid (h2) - sc-408750-NIC-2 from Santa Cruz Biotechnology
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MOX-1 CRISPR Activation Plasmid (h) - sc-408750-ACT from Santa Cruz Biotechnology
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MOX-1 CRISPR Activation Plasmid (h2) - sc-408750-ACT-2 from Santa Cruz Biotechnology
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MOX-1 Lentiviral Activation Particles (h) - sc-408750-LAC from Santa Cruz Biotechnology
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MOX-1 Lentiviral Activation Particles (h2) - sc-408750-LAC-2 from Santa Cruz Biotechnology
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MOX-1 siRNA (h) - sc-43938 from Santa Cruz Biotechnology
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MOX-1 shRNA Plasmid (h) - sc-43938-SH from Santa Cruz Biotechnology
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MOX-1 shRNA (h) Lentiviral Particles - sc-43938-V from Santa Cruz Biotechnology
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MOX1 RNAi - H00004222-R02 from Novus Biologicals
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MISSION® esiRNA - EHU085721 from Sigma-Aldrich
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MISSION® esiRNA - EHU118731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13204 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13204 from Sigma-Aldrich
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MEOX1 siRNA (Human) - CRH2871 from Cohesion Biosciences
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MOX1 RNAi - H00004222-R01 from Novus Biologicals
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shRNA set against Human MEOX1 (NM_004527.3) - SHH340403 from Creative biogene
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shRNA set against Human MEOX1(NM_013999.3) - SHH184637 from Creative biogene
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shRNA set against Human MEOX1(NM_004527.3) - SHH184655 from Creative biogene
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shRNA set against Human MEOX1(NM_001040002.1) - SHH184673 from Creative biogene
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Human MEOX1 siRNA - orb263373 from Biorbyt
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MEOX1 shRNA Plasmid (Human) - CHH2871 from Cohesion Biosciences
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MEOX1 miRNA 3'UTR clone - MiUTR1H-06204 from Creative biogene
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