| Gene Symbol |
GRIA2
|
| Entrez Gene |
2891
|
| Alt Symbol |
GLUR2, GLURB, GluA2, GluR-K2, HBGR2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glutamate receptor, ionotropic, AMPA 2
|
| Other Description |
AMPA-selective glutamate receptor 2|gluR-2|gluR-B|glutamate receptor 2
|
| Swissprots |
A8MT92 I6L997 Q96FP6 P42262
|
| Accessions |
AAF23955 EAX04865 EAX04866 EAX04867 EAX04868 EAX04869 EAX04870 EAX04871 P42262 AB209567 BAD92804 AK294458 BAH11774 AK308775 AK309067 AL708924 AL832605 BC010574 AAH10574 BC028736 AAH28736 BP202382 BP202686 DA228330 DA810082 FJ460423 ACJ74177 FJ460424 ACJ74178 FJ460425 ACJ74179 FJ460426 ACJ74180 FJ460427 ACJ74181 FJ460428 ACJ74182 FJ460429 ACJ74183 FJ460430 ACJ74184 FJ460431 ACJ74185 FJ460432 ACJ74186 JN547408 AEQ93812 L20814 AAA58631 X64829 X64830 XM_011531892 XP_011530194 XR_938725 NM_000826 NP_000817 NM_001083619 NP_001077088 NM_001083620 NP_001077089
|
| Function |
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO:0000269|PubMed:20614889}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. {ECO:0000250}.
|
| Top Pathways |
Amphetamine addiction, cAMP signaling pathway, Circadian entrainment, Cocaine addiction, Retrograde endocannabinoid signaling
|