GRIA2

Gene Symbol	GRIA2
Entrez Gene	2891
Alt Symbol	GLUR2, GLURB, GluA2, GluR-K2, HBGR2
Species	Human
Gene Type	protein-coding
Description	glutamate receptor, ionotropic, AMPA 2
Other Description	AMPA-selective glutamate receptor 2|gluR-2|gluR-B|glutamate receptor 2
Swissprots	A8MT92 I6L997 Q96FP6 P42262
Accessions	AAF23955 EAX04865 EAX04866 EAX04867 EAX04868 EAX04869 EAX04870 EAX04871 P42262 AB209567 BAD92804 AK294458 BAH11774 AK308775 AK309067 AL708924 AL832605 BC010574 AAH10574 BC028736 AAH28736 BP202382 BP202686 DA228330 DA810082 FJ460423 ACJ74177 FJ460424 ACJ74178 FJ460425 ACJ74179 FJ460426 ACJ74180 FJ460427 ACJ74181 FJ460428 ACJ74182 FJ460429 ACJ74183 FJ460430 ACJ74184 FJ460431 ACJ74185 FJ460432 ACJ74186 JN547408 AEQ93812 L20814 AAA58631 X64829 X64830 XM_011531892 XP_011530194 XR_938725 NM_000826 NP_000817 NM_001083619 NP_001077088 NM_001083620 NP_001077089
Function	Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO:0000269|PubMed:20614889}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. {ECO:0000250}.
Top Pathways	Amphetamine addiction, cAMP signaling pathway, Circadian entrainment, Cocaine addiction, Retrograde endocannabinoid signaling

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Ionotropic Glutamate receptor 2 protein fragment - ab151661 from Abcam Category Protein Source HEK 293 cells Species Human

Mouse Ionotropic Glutamate receptor 2 peptide - ab25708 from Abcam Category Peptide

GRIA2 / GLUR2 Antibody Blocking Peptide - LS-E10697 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GRIA2 / GLUR2 Antibody Blocking Peptide - LS-E10698 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SYNTHETIC Human GluR2 Protein (OPSA10524) - OPSA10524 from Aviva Systems Biology Category Protein Prices $160.00 Sizes 50 µg Species Human

GRIA2 Blocking Peptide - 33R-7323 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

GRIA2 Blocking Peptide - 33R-8887 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Glutamate receptor 2 / GLUR2 control peptide - AP10083CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

Glutamate Receptor 2, GLUR2, Human, Recombinant - 19-C521 from ARP American Research Products Category Protein Prices $119.00 Sizes 10 µg Source HEK293 Species Human

GRIA2 fusion protein - ag20353 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

GRIA2 fusion protein - ag2662 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human GLUR2 Protein - BP001523-C521 from Syd Labs Category Protein Prices $126.00, $378.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source HEK 293-derived. Species Human

Recombinant Human GRIA2, His-tagged - GRIA2-7955H from Creative Biomart Category Protein Source HEK293 Cells Species Human

Recombinant Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2) - RPE802Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2) - RPE802Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2) - RPE802Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

GLUR2 Blocking Peptide - CBP1501 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Chicken, Monkey, Zebrafish

GLUR2 (pS880) Blocking Peptide - CBP3975 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Chicken, Monkey, Zebrafish

GluR2 (Y873) Peptide - BS3658P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

p-GluR-2 (S880) Peptide - BS4794P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

GluR2 - 4670-5144 from AbD Serotec Category Protein Prices $125.00 Sizes 50 µg Source Solid phase synthesis Species Human

Glutamate receptor 2(Precursor)(phospho-Ser880) antibody blocking peptide - 51292 from Signalway Antibody Category Peptide Prices $70.00 Sizes 100 µl

Glutamate Receptor, Ionotropic, AMPA 2 Protein (Recombinant) - abx168238 from Abbexa Category Protein Source Human Species Human

GluR2 Recombinant Protein Antigen - NBP1-89765PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

GLUR2 (pS880) Blocking Peptide - abx162468 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken, Monkey, Zebrafish

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