GRIA2

Gene Symbol GRIA2
Entrez Gene 2891
Alt Symbol GLUR2, GLURB, GluA2, GluR-K2, HBGR2
Species Human
Gene Type protein-coding
Description glutamate receptor, ionotropic, AMPA 2
Other Description AMPA-selective glutamate receptor 2|gluR-2|gluR-B|glutamate receptor 2
Swissprots A8MT92 I6L997 Q96FP6 P42262
Accessions AAF23955 EAX04865 EAX04866 EAX04867 EAX04868 EAX04869 EAX04870 EAX04871 P42262 AB209567 BAD92804 AK294458 BAH11774 AK308775 AK309067 AL708924 AL832605 BC010574 AAH10574 BC028736 AAH28736 BP202382 BP202686 DA228330 DA810082 FJ460423 ACJ74177 FJ460424 ACJ74178 FJ460425 ACJ74179 FJ460426 ACJ74180 FJ460427 ACJ74181 FJ460428 ACJ74182 FJ460429 ACJ74183 FJ460430 ACJ74184 FJ460431 ACJ74185 FJ460432 ACJ74186 JN547408 AEQ93812 L20814 AAA58631 X64829 X64830 XM_011531892 XP_011530194 XR_938725 NM_000826 NP_000817 NM_001083619 NP_001077088 NM_001083620 NP_001077089
Function Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO:0000269|PubMed:20614889}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. {ECO:0000250}.
Top Pathways Amphetamine addiction, cAMP signaling pathway, Circadian entrainment, Cocaine addiction, Retrograde endocannabinoid signaling

GluR-2 CRISPR/Cas9 KO Plasmid (h) - sc-402035 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GluR-2 HDR Plasmid (h) - sc-402035-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GluR-2 Double Nickase Plasmid (h) - sc-402035-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GluR-2 Double Nickase Plasmid (h2) - sc-402035-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GluR-2 CRISPR Activation Plasmid (h) - sc-402035-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GluR-2 CRISPR Activation Plasmid (h2) - sc-402035-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GluR-2 Lentiviral Activation Particles (h) - sc-402035-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GluR-2 Lentiviral Activation Particles (h2) - sc-402035-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GluR-2 siRNA (h) - sc-35487 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GluR-2 shRNA Plasmid (h) - sc-35487-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GluR-2 shRNA (h) Lentiviral Particles - sc-35487-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GluR2 RNAi - H00002891-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU096331 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU140711 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9676 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9676 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12961 from Sigma-Aldrich

Category miRNA

GRIA2 siRNA (Human) - CRH1945 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GRIA2 - MBS8204439 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GRIA2 (NM_000826.3) - SHH307742 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human GRIA2(NM_001083619.1) - SHH103781 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human GRIA2(NM_000826.3) - SHH103799 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human GRIA2(NM_001083620.1) - SHH103853 from Creative biogene

Category siRNA
Species Reactivities Human

GRIA2 shRNA Plasmid (Human) - CHH1945 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GRIA2 miRNA 3'UTR clone - MiUTR1H-04260 from Creative biogene

Species Reactivities Human
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