GRIA2

Gene Symbol GRIA2
Entrez Gene 2891
Alt Symbol GLUR2, GLURB, GluA2, GluR-K2, HBGR2
Species Human
Gene Type protein-coding
Description glutamate receptor, ionotropic, AMPA 2
Other Description AMPA-selective glutamate receptor 2|gluR-2|gluR-B|glutamate receptor 2
Swissprots A8MT92 I6L997 Q96FP6 P42262
Accessions AAF23955 EAX04865 EAX04866 EAX04867 EAX04868 EAX04869 EAX04870 EAX04871 P42262 AB209567 BAD92804 AK294458 BAH11774 AK308775 AK309067 AL708924 AL832605 BC010574 AAH10574 BC028736 AAH28736 BP202382 BP202686 DA228330 DA810082 FJ460423 ACJ74177 FJ460424 ACJ74178 FJ460425 ACJ74179 FJ460426 ACJ74180 FJ460427 ACJ74181 FJ460428 ACJ74182 FJ460429 ACJ74183 FJ460430 ACJ74184 FJ460431 ACJ74185 FJ460432 ACJ74186 JN547408 AEQ93812 L20814 AAA58631 X64829 X64830 XM_011531892 XP_011530194 XR_938725 NM_000826 NP_000817 NM_001083619 NP_001077088 NM_001083620 NP_001077089
Function Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO:0000269|PubMed:20614889}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. {ECO:0000250}.
Top Pathways Amphetamine addiction, cAMP signaling pathway, Circadian entrainment, Cocaine addiction, Retrograde endocannabinoid signaling

Phospho-AMPA Receptor (GluR 2) (Tyr876) Antibody - 4027 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from rat brain, either sham-operated, 15 min ischemia followed by 4 h reperfusion or 15 min ischemia only, using Phospho-AMPA Receptor (GluR 2) (Tyr876) Antibody (upper) or AMPA Receptor (GluR 2/3/4) Antibody #2460 (lower).

Phospho-AMPA Receptor (GluR 2) (Tyr869/Tyr873/Tyr876) Antibody - 3921 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from rat brain, either 15 min ischemia followed by 4 h reperfusion or 15 min ischemia only, using Phospho-AMPA Receptor (GluR 2) (Ty869/Tyr873/Tyr876) Antibody (upper) or AMPA Receptor (GluR 2/3/4) Antibody #2460 (lower).

AMPA Receptor (GluR 2/3/4) Antibody - 2460 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from rat and mouse brain using AMPA Receptor (GluR 2/3/4) Antibody.

AMPA Receptor (GluR 2) (E1L8U) Rabbit mAb - 13607 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone E1L8U
Western blot analysis of extracts from mouse brain, rat brain, and human cortex tissues using AMPA Receptor (GluR 2) (E1L8U) Rabbit mAb.

AMPA Receptor (GluR 2) (D39F2) Rabbit mAb - 5306 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D39F2
Western blot analysis of extracts from mouse and rat brains using AMPA Receptor (GluR 2) (D39F2) Rabbit mAb.

GluR-1/2/3/4 (H-180) - sc-33612 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

GluR-2 (C-20) - sc-7610 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GluR-2 (C-20) PE: sc-7610 PE. Intracellular FCM analysis of fixed and permeabilized SK-N-SH cells. Black line histogram represents the isotype control, normal goat IgG: sc-3992.

GluR-2 (N-19) - sc-7611 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GluR-2 (N-19) PE: sc-7611 PE. Intracellular FCM analysis of fixed and permeabilized BC<sub>3</sub>H1 cells. Black line histogram represents the isotype control, normal goat IgG: sc-3992.

p-GluR-2/3 (Ser 880/Ser 891) - sc-17088 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-GluR-2/3 (Ser 880 / Ser 891): sc-17088. Western blot analysis of GluR-2/3 phosphorylation in rat brain (A) and mouse brain (B) tissue extracts.

p-GluR-2/3 (Ser 880/Ser 891) - sc-101689 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of phosphorylated GluR-2/3 expression in mouse brain tissue extract. Blots were probed with p-GluR-2/3 (Ser 880/Ser 891): sc-101689 preincubated with cognate phosphorylated peptide (A) and p-GluR-2/3 (Ser 880/Ser 891): sc-101689 (B).

Anti-Ionotropic glutamate receptor 2 + 3 antibody - ab27225 from Abcam

Prices $379.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Ab27225 at a dilution of 1/50, staining ionotropic Glutamate Receptor 2+3 in Human cerebellum by Immunohistochemistry (formalin fixed, paraffin embedded sections).

Anti-Ionotropic glutamate receptor 2 + 3 antibody - ab53086 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Ionotropic glutamate receptor 2 + 3 antibody (ab53086) at 1/500 dilutionLane 1 : Mouse brain extractLane 2 : Mouse brain extract with peptide

Anti-Ionotropic glutamate receptor 2 + 3 antibody - ab37174 from Abcam

Prices $359.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Ionotropic glutamate receptor 2 + 3 antibody (ab37174) at 1/1000 dilution + rat brain hippocampus lysate at 10 µg

Anti-Ionotropic glutamate receptor 2 + 3 antibody [EP929Y] - ab52896 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP929Y
Anti-Ionotropic glutamate receptor 2 + 3 antibody [EP929Y] (ab52896) at 1/5000 dilution + human brain lysate at 10 µgSecondarygoat anti-rabbit HRP at 1/2000 dilution

Anti-Ionotropic glutamate receptor 2 + 3 antibody, prediluted - ab15302 from Abcam

Prices $370.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal

Anti-Ionotropic Glutamate receptor 2 (phospho S880) antibody - ab52180 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Ionotropic Glutamate receptor 2 (phospho S880) antibody (ab52180) at 1/500 dilutionLane 1 : extracts from mouse brainLane 2 : extracts from mouse brain with blocking phosphopeptide

Anti-Ionotropic Glutamate receptor 2 (phospho S880) antibody - ab195705 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Ionotropic Glutamate receptor 2 (phospho S880) antibody (ab195705) at 1/500 dilutionLane 1 : Mouse brain tissue lysate with antigen-specific peptideLane 2 : Mouse brain tissue lysate

Anti-Ionotropic Glutamate receptor 2 antibody - ab20673 from Abcam

Prices $382.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : MarkerLanes 2 - 5 : Anti-Ionotropic Glutamate receptor 2 antibody (ab20673) at 1 µg/mlLane 1 : As aboveLane 2 : Brain (Mouse) Tissue Lysate at 10 µgLane 3 : Cortex (Mouse) Tissue Lysate at 10 µgLane 4 : Brain (Mouse) Tissue Lysate at 10 µg with Mouse Ionotropic Glutamate receptor 2 peptide (ab25708) at 1 µg/mlLane 5 : Cortex (Mouse) Tissue Lysate at 10 µg with Mouse Ionotropic Glutamate receptor 2 peptide (ab25708) at 1 µg/mlSecondaryLanes 2 - 5 : IRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-Ionotropic Glutamate receptor 2 antibody - ab52176 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab52176 at 1/50 dilution staining Ionotropic Glutamate receptor 2 in human brain by Immunohistochemistry, paraffin embedded tissue, in the presence (right image) and absence (left image) of the immunizing peptide.

Anti-Ionotropic Glutamate receptor 2 antibody - ab101887 from Abcam

Host Goat
Clonality Polyclonal

Anti-Ionotropic Glutamate receptor 2 antibody - ab87605 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-Ionotropic Glutamate receptor 2 antibody [7G6] - ab135367 from Abcam

Host Mouse
Clonality Monoclonal
Clone 7G6
Anti-Ionotropic Glutamate receptor 2 antibody [7G6] (ab135367) at 1/500 dilution + Ionotropic Glutamate receptor 2 recombinant protein

Anti-Ionotropic Glutamate receptor 2 antibody [EP966Y] - ab52932 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP966Y
Anti-Ionotropic Glutamate receptor 2 antibody [EP966Y] (ab52932) at 1/2000 dilution + Human brain cell lysate at 10 µgSecondaryGoat anti-Rabbit HRP labeled at 1/2000 dilution

Anti-Ionotropic Glutamate receptor 2 antibody [EPR5032] - ab133477 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5032
ab133477 staining GluR2 in SK-N-SH cells treated with VU 0360223 (ab120803), by ICC/IF. Decrease of GluR2 expression correlates with increased concentration of VU 0360223, as described in literature.The cells were incubated at 37°C for 6h in media containing different concentrations of ab120803 (VU 0360223) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab133477 (1/200 dilution was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Anti-Ionotropic Glutamate receptor 2 antibody [EPR5032] (Alexa Fluor® 488) - ab199777 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5032
ab199777 staining Ionotropic Glutamate receptor 2 in SKNSH cells. The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab199777 at 1/100 dilution (shown in green) and ab195889, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 594), at 2µg/ml (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).
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