Gene Symbol |
ALOX5AP
|
Entrez Gene |
241
|
Alt Symbol |
FLAP
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
arachidonate 5-lipoxygenase-activating protein
|
Other Description |
MK-886-binding protein
|
Swissprots |
Q5VV04 P20292
|
Accessions |
AAA35845 AAT38104 EAX08467 P20292 AK314143 BC018538 AAH18538 BG569867 BQ003388 DQ891647 ABM82573 DQ894836 ABM85762 XM_011535024 XP_011533326 XM_011535025 XP_011533327 NM_001204406 NP_001191335 NM_001629 NP_001620
|
Function |
Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. {ECO:0000269|PubMed:2300173, ECO:0000269|PubMed:8440384}.
|
Subcellular Location |
Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
|