Gene Symbol | ALOX5AP |
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Entrez Gene | 241 |
Alt Symbol | FLAP |
Species | Human |
Gene Type | protein-coding |
Description | arachidonate 5-lipoxygenase-activating protein |
Other Description | MK-886-binding protein |
Swissprots | Q5VV04 P20292 |
Accessions | AAA35845 AAT38104 EAX08467 P20292 AK314143 BC018538 AAH18538 BG569867 BQ003388 DQ891647 ABM82573 DQ894836 ABM85762 XM_011535024 XP_011533326 XM_011535025 XP_011533327 NM_001204406 NP_001191335 NM_001629 NP_001620 |
Function | Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. {ECO:0000269|PubMed:2300173, ECO:0000269|PubMed:8440384}. |
Subcellular Location | Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. |
FLAP CRISPR/Cas9 KO Plasmid (h) - sc-402268 from Santa Cruz Biotechnology
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FLAP HDR Plasmid (h) - sc-402268-HDR from Santa Cruz Biotechnology
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FLAP Double Nickase Plasmid (h) - sc-402268-NIC from Santa Cruz Biotechnology
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FLAP Double Nickase Plasmid (h2) - sc-402268-NIC-2 from Santa Cruz Biotechnology
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FLAP CRISPR Activation Plasmid (h) - sc-402268-ACT from Santa Cruz Biotechnology
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FLAP CRISPR Activation Plasmid (h2) - sc-402268-ACT-2 from Santa Cruz Biotechnology
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FLAP Lentiviral Activation Particles (h) - sc-402268-LAC from Santa Cruz Biotechnology
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FLAP Lentiviral Activation Particles (h2) - sc-402268-LAC-2 from Santa Cruz Biotechnology
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FLAP siRNA (h) - sc-41394 from Santa Cruz Biotechnology
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FLAP shRNA Plasmid (h) - sc-41394-SH from Santa Cruz Biotechnology
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FLAP shRNA (h) Lentiviral Particles - sc-41394-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU015971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3081 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02163 from Sigma-Aldrich
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ALOX5AP siRNA (Human) - CRH0168 from Cohesion Biosciences
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ALOX5AP - MBS8221389 from MyBioSource
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shRNA set against Human ALOX5AP (NM_001629.3) - SHH235399 from Creative biogene
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Human ALOX5AP siRNA - orb260670 from Biorbyt
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ALOX5AP shRNA Plasmid (Human) - CHH0168 from Cohesion Biosciences
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ALOX5AP miRNA 3'UTR clone - MiUTR3H-06191 from Creative biogene
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