Gene Symbol | ALOX5AP |
---|---|
Entrez Gene | 241 |
Alt Symbol | FLAP |
Species | Human |
Gene Type | protein-coding |
Description | arachidonate 5-lipoxygenase-activating protein |
Other Description | MK-886-binding protein |
Swissprots | Q5VV04 P20292 |
Accessions | AAA35845 AAT38104 EAX08467 P20292 AK314143 BC018538 AAH18538 BG569867 BQ003388 DQ891647 ABM82573 DQ894836 ABM85762 XM_011535024 XP_011533326 XM_011535025 XP_011533327 NM_001204406 NP_001191335 NM_001629 NP_001620 |
Function | Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. {ECO:0000269|PubMed:2300173, ECO:0000269|PubMed:8440384}. |
Subcellular Location | Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. |