MRC2

Gene Symbol	MRC2
Entrez Gene	9902
Alt Symbol	CD280, CLEC13E, ENDO180, UPARAP
Species	Human
Gene Type	protein-coding
Description	mannose receptor, C type 2
Other Description	C-type lectin domain family 13 member E|C-type mannose receptor 2|UPAR-associated protein|endocytic receptor (macrophage mannose receptor family)|endocytic receptor 180|macrophage mannose receptor 2|urokinase-type plasminogen activator receptor-associated protein
Swissprots	Q9Y5P9 Q7LGE7 D3DU08 A6H8K4 Q9UBG0
Accessions	EAW94341 EAW94342 Q9UBG0 AB014609 BAA31684 AF107292 AAF14192 AF134838 AAD30280 AI458446 AK093230 BAG52674 AY429551 BC032763 BC146647 AAI46648 BC150212 AAI50213 BC153884 AAI53885 BX111813 U58856 AAC51365 XM_011525543 XP_011523845 XR_934628 NM_006039 NP_006030
Function	May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). {ECO:0000269|PubMed:10683150, ECO:0000269|PubMed:12972549}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney. {ECO:0000269|PubMed:10683150, ECO:0000269|PubMed:8702911}.
Top Pathways	Phagosome, Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Endo180 (B-10) - sc-271148 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Endo180 (H-300) - sc-68371 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Endo180 (E-17) - sc-68076 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Endo180 (C-17) - sc-68075 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Endo180 (S-20) - sc-68078 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-MRC2 antibody - ab70132 from Abcam Prices $401.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MRC2 antibody - ab124250 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-MRC2 antibody - ab56883 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-MRC2 antibody [EPR13215] - ab181075 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR13215

Anti-MRC2 / Endo180 Antibody (aa800-1059) - LS-C125960 from LifeSpan Bioscience Prices $605.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-MRC2 / Endo180 Antibody (aa31-1413) - LS-C72784 from LifeSpan Bioscience Prices $605.00 Sizes 100 µg Host Sheep Clonality Polyclonal

Anti-MRC2 / Endo180 Antibody (aa797-827, APC) - LS-C237757 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MRC2 / Endo180 Antibody (aa797-827, Biotin) - LS-C237758 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MRC2 / Endo180 Antibody (aa797-827, AP) - LS-C237759 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MRC2 / Endo180 Antibody (aa797-827, FITC) - LS-C237760 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MRC2 / Endo180 Antibody (aa797-827, PE) - LS-C237761 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MRC2 / Endo180 Antibody (aa797-827, Azide-free, HRP) - LS-C248843 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MRC2 / Endo180 Antibody (aa105-214) - LS-C309058 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-MRC2 / Endo180 Antibody (aa797-827) - LS-C329843 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MRC2 / Endo180 Antibody (Gly145) - LS-C192041 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MRC2 / Endo180 Antibody (aa798-827) - LS-C164622 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-MRC2 / Endo180 Antibody (aa121-170) - LS-C119298 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Mrc2 Antibody - AF5770 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Goat Clonality Polyclonal

Mrc2 Antibody - NBP1-85768 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Mrc2 Antibody (2D7) - H00009902-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2D7

Search more