MRC2

Gene Symbol	MRC2
Entrez Gene	9902
Alt Symbol	CD280, CLEC13E, ENDO180, UPARAP
Species	Human
Gene Type	protein-coding
Description	mannose receptor, C type 2
Other Description	C-type lectin domain family 13 member E|C-type mannose receptor 2|UPAR-associated protein|endocytic receptor (macrophage mannose receptor family)|endocytic receptor 180|macrophage mannose receptor 2|urokinase-type plasminogen activator receptor-associated protein
Swissprots	Q9Y5P9 Q7LGE7 D3DU08 A6H8K4 Q9UBG0
Accessions	EAW94341 EAW94342 Q9UBG0 AB014609 BAA31684 AF107292 AAF14192 AF134838 AAD30280 AI458446 AK093230 BAG52674 AY429551 BC032763 BC146647 AAI46648 BC150212 AAI50213 BC153884 AAI53885 BX111813 U58856 AAC51365 XM_011525543 XP_011523845 XR_934628 NM_006039 NP_006030
Function	May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). {ECO:0000269|PubMed:10683150, ECO:0000269|PubMed:12972549}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney. {ECO:0000269|PubMed:10683150, ECO:0000269|PubMed:8702911}.
Top Pathways	Phagosome, Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human MRC2 protein fragment - ab112386 from Abcam Category Protein Source Wheat germ Species Human

MRC2 Antibody Blocking Peptide - LS-E3877 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Mrc2 Partial Recombinant Protein - H00009902-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MRC2-Antibody-Center-Blocking-Peptide - BP16060c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CD280 / MRC2 - H00009902-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD280 / MRC2 - H00009902-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MRC2 fusion protein - Ag16621 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

MRC2 fusion protein - ag15570 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human MRC2 - MRC2-29703TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human MRC2 - MRC2-1133H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Mannose Receptor C Type 2 (MRC2) - RPA733Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Mannose Receptor C Type 2 (MRC2) - RPA733Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Mannose Receptor C Type 2 (MRC2) - RPA733Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Endo180 (G145) Peptide - BS2506P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Mannose Receptor C Type 2 (MRC2) - RPA733Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human C-type mannose receptor 2(MRC2) ,partial - CSB-YP871380HU CSB-EP871380HU CSB-BP871380HU CSB-MP871380HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CD280 / MRC2 - TP321360 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

C-type mannose receptor 2 (MRC2), partial, Recombinant Protein - MBS1405981 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Mrc2 Recombinant Protein Antigen - NBP1-85768PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MRC2 Peptide, Human - M34GP09701H from Creative Peptides Category Peptide Source Synthetic. Species Human

MRC2 Recombinant Protein (OPCD05391) - OPCD05391 from Aviva Systems Biology Category Protein Source E.coli Species Human

Mannose Receptor C Type 2, Recombinant Protein - MBS2031585 from MyBioSource Category Protein Prices $190.00, $410.00, $635.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Recombinant Human MRC2 Protein, MYC/DDK-tagged - MRC2-22H from Creative Biomart Category Protein Source HEK293 Species Human

Search more