MRC2
| Gene Symbol | MRC2 |
|---|---|
| Entrez Gene | 9902 |
| Alt Symbol | CD280, CLEC13E, ENDO180, UPARAP |
| Species | Human |
| Gene Type | protein-coding |
| Description | mannose receptor, C type 2 |
| Other Description | C-type lectin domain family 13 member E|C-type mannose receptor 2|UPAR-associated protein|endocytic receptor (macrophage mannose receptor family)|endocytic receptor 180|macrophage mannose receptor 2|urokinase-type plasminogen activator receptor-associated protein |
| Swissprots | Q9Y5P9 Q7LGE7 D3DU08 A6H8K4 Q9UBG0 |
| Accessions | EAW94341 EAW94342 Q9UBG0 AB014609 BAA31684 AF107292 AAF14192 AF134838 AAD30280 AI458446 AK093230 BAG52674 AY429551 BC032763 BC146647 AAI46648 BC150212 AAI50213 BC153884 AAI53885 BX111813 U58856 AAC51365 XM_011525543 XP_011523845 XR_934628 NM_006039 NP_006030 |
| Function | May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). {ECO:0000269|PubMed:10683150, ECO:0000269|PubMed:12972549}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney. {ECO:0000269|PubMed:10683150, ECO:0000269|PubMed:8702911}. |
| Top Pathways | Phagosome, Tuberculosis |
Endo180 CRISPR/Cas9 KO Plasmid (h) - sc-403483 from Santa Cruz Biotechnology
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Endo180 HDR Plasmid (h) - sc-403483-HDR from Santa Cruz Biotechnology
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Endo180 Double Nickase Plasmid (h) - sc-403483-NIC from Santa Cruz Biotechnology
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Endo180 Double Nickase Plasmid (h2) - sc-403483-NIC-2 from Santa Cruz Biotechnology
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Endo180 CRISPR Activation Plasmid (h) - sc-403483-ACT from Santa Cruz Biotechnology
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Endo180 CRISPR Activation Plasmid (h2) - sc-403483-ACT-2 from Santa Cruz Biotechnology
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Endo180 Lentiviral Activation Particles (h) - sc-403483-LAC from Santa Cruz Biotechnology
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Endo180 Lentiviral Activation Particles (h2) - sc-403483-LAC-2 from Santa Cruz Biotechnology
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Endo180 siRNA (h) - sc-62276 from Santa Cruz Biotechnology
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Endo180 shRNA Plasmid (h) - sc-62276-SH from Santa Cruz Biotechnology
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Endo180 shRNA (h) Lentiviral Particles - sc-62276-V from Santa Cruz Biotechnology
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Mrc2 RNAi - H00009902-R04 from Novus Biologicals
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MISSION® esiRNA - EHU003351 from Sigma-Aldrich
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MISSION® esiRNA - EHU025531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14527 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14527 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08174 from Sigma-Aldrich
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MRC2 siRNA (Human) - CRH6647 from Cohesion Biosciences
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Endo180 CRISPR/Cas9 KO Plasmid (h2) - sc-403483-KO-2 from Santa Cruz Biotechnology
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Endo180 HDR Plasmid (h2) - sc-403483-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human MRC2 (NM_006039.4) - SHH344208 from Creative biogene
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Human MRC2 siRNA - orb267149 from Biorbyt
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MRC2 shRNA Plasmid (Human) - CHH6647 from Cohesion Biosciences
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MRC2 miRNA 3'UTR clone - MiUTR3H-12363 from Creative biogene
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