| Gene Symbol |
MRC2
|
| Entrez Gene |
9902
|
| Alt Symbol |
CD280, CLEC13E, ENDO180, UPARAP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mannose receptor, C type 2
|
| Other Description |
C-type lectin domain family 13 member E|C-type mannose receptor 2|UPAR-associated protein|endocytic receptor (macrophage mannose receptor family)|endocytic receptor 180|macrophage mannose receptor 2|urokinase-type plasminogen activator receptor-associated protein
|
| Swissprots |
Q9Y5P9 Q7LGE7 D3DU08 A6H8K4 Q9UBG0
|
| Accessions |
EAW94341 EAW94342 Q9UBG0 AB014609 BAA31684 AF107292 AAF14192 AF134838 AAD30280 AI458446 AK093230 BAG52674 AY429551 BC032763 BC146647 AAI46648 BC150212 AAI50213 BC153884 AAI53885 BX111813 U58856 AAC51365 XM_011525543 XP_011523845 XR_934628 NM_006039 NP_006030
|
| Function |
May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). {ECO:0000269|PubMed:10683150, ECO:0000269|PubMed:12972549}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney. {ECO:0000269|PubMed:10683150, ECO:0000269|PubMed:8702911}.
|
| Top Pathways |
Phagosome, Tuberculosis
|