PDCD6

Gene Symbol PDCD6
Entrez Gene 10016
Alt Symbol ALG-2, ALG2, PEF1B
Species Human
Gene Type protein-coding
Description programmed cell death 6
Other Description apoptosis-linked gene 2 protein|probable calcium-binding protein ALG-2|programmed cell death protein 6
Swissprots O75340 B2RD16 E7ESR3 Q5TZS0 Q2YDC2
Accessions EAW50987 EAW50990 EAW50991 O75340 AF035606 AAC27697 AK001917 AK024175 AK124302 AK128087 BAC87267 AK223366 BAD97086 AK295082 BAG58124 AK308872 AK310347 AK315370 BAG37763 AW300963 BC012384 AAH12384 BC028242 BC050597 AAH50597 BC106706 AAI06707 BC110291 AAI10292 BG390506 BI553617 BT020072 AAV38875 CR983268 DB495449 DQ891163 ABM82089 DQ894344 ABM85270 U58773 AAF14336 NM_001267556 NP_001254485 NM_001267557 NP_001254486 NM_001267558 NP_001254487 NM_001267559 NP_001254488 NM_013232 NP_037364 NR_073609
Function Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Seems to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca(2+) affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5. {ECO:0000250, ECO:0000269|PubMed:16132846, ECO:0000269|PubMed:17889823, ECO:0000269|PubMed:19520058, ECO:0000269|PubMed:19864416, ECO:0000269|PubMed:21893193}.
Subcellular Location Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Endosome. Note=Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus. Translocated from the cytoplasm to the nucleus after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules.

ALG-2 (FL-191) - sc-292580 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ALG-2 (FL-191): sc-292580. Western blot analysis of ALG-2 expression in non-transfected: sc-117752 (A) and human ALG-2 transfected: sc-112988 (B) 293T whole cell lysates.

ALG-2 (H-11) - sc-376950 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ALG-2 (H-11): sc-376950. Western blot analysis of ALG-2 expression in non-transfected: sc-117752 (A) and human ALG-2 transfected: sc-114742 (B) 293T whole cell lysates.

ALG-2 (H-14) - sc-11255 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ALG-2 (H-14): sc-11255. Western blot analysis of ALG-2 expression in non-transfected: sc-117752 (A) and human ALG-2 transfected: sc-114742 (B) 293T whole cell lysates.

ALG-2 (AA8) - sc-101209 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
ALG-2 (AA8): sc-101209. Western blot analysis of ALG-2 expression in non-transfected: sc-117752 (A) and human ALG-2 transfected: sc-112988 (B) 293T whole cell lysates.

Anti-PDCD6 antibody - ab197679 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PDCD6 antibody (ab197679) at 1/200 dilutionLane 1 : Jurkat cell lysateLane 2 : HeLa cell lysateLysates/proteins at 50 µg per lane.

Anti-PDCD6 antibody - ab56933 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-PDCD6 antibody [EP3259] - ab109181 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP3259
All lanes : Anti-PDCD6 antibody [EP3259] (ab109181) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : HeLa cell lysateLane 3 : 293T cell lysateLysates/proteins at 10 µg per lane.

Anti-PDCD6 antibody [EPR3260] - ab133326 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3260
All lanes : Anti-PDCD6 antibody [EPR3260] (ab133326) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Jurkat cell lysateLane 3 : HepG2 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-PDCD6 antibody, prediluted - ab64104 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of PDCD6 expression in human lung carcinoma using ab64104 on formalin-fixed, paraffin-embedded tissue. Staining pattern: Cytoplasmic and cell membrane.

Anti-PDCD6 antibody - Carboxyterminal end - ab64151 from Abcam

Prices $376.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of PDCD6 expression in human lung carcinoma using ab64151, at 1/50 dilution, on formalin-fixed, paraffin-embedded tissue. Staining pattern: Cytoplasmic and cell membrane.

Anti-PDCD6 antibody - N-terminal - ab156231 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PDCD6 antibody - N-terminal (ab156231) at 1/100 dilution + A549 cell line lysates at 35 µg

Anti-PDCD6 / ALG-2 Antibody (C-Terminus) - LS-C50532 from LifeSpan Bioscience

Prices $530.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal
Human lung carcinoma stained with Anti-PDCD6

Anti-PDCD6 / ALG-2 Antibody - LS-C211721 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDCD6 / ALG-2 Antibody (HRP) - LS-C211722 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDCD6 / ALG-2 Antibody (FITC) - LS-C211723 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDCD6 / ALG-2 Antibody (Biotin) - LS-C211724 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDCD6 / ALG-2 Antibody (aa19-47, AP) - LS-C238876 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDCD6 / ALG-2 Antibody (Internal, clone EPR3260) - LS-C138613 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3260
Western blot analysis on (A) HeLa, (B) Jurkat, and (C) HepG2 cell lysates using anti-PDCD6 antibody.

Anti-PDCD6 / ALG-2 Antibody (aa19-47, Biotin) - LS-C238877 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDCD6 / ALG-2 Antibody (aa19-47, APC) - LS-C238878 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDCD6 / ALG-2 Antibody (aa19-47, FITC) - LS-C238879 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDCD6 / ALG-2 Antibody (aa19-47, PE) - LS-C238881 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDCD6 / ALG-2 Antibody (aa19-47, Azide-free, HRP) - LS-C248440 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDCD6 / ALG-2 Antibody (aa19-47) - LS-C323878 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDCD6 / ALG-2 Antibody (aa92-191, Azide-free) - LS-C328171 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
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