| Gene Symbol |
PDCD6
|
| Entrez Gene |
10016
|
| Alt Symbol |
ALG-2, ALG2, PEF1B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
programmed cell death 6
|
| Other Description |
apoptosis-linked gene 2 protein|probable calcium-binding protein ALG-2|programmed cell death protein 6
|
| Swissprots |
O75340 B2RD16 E7ESR3 Q5TZS0 Q2YDC2
|
| Accessions |
EAW50987 EAW50990 EAW50991 O75340 AF035606 AAC27697 AK001917 AK024175 AK124302 AK128087 BAC87267 AK223366 BAD97086 AK295082 BAG58124 AK308872 AK310347 AK315370 BAG37763 AW300963 BC012384 AAH12384 BC028242 BC050597 AAH50597 BC106706 AAI06707 BC110291 AAI10292 BG390506 BI553617 BT020072 AAV38875 CR983268 DB495449 DQ891163 ABM82089 DQ894344 ABM85270 U58773 AAF14336 NM_001267556 NP_001254485 NM_001267557 NP_001254486 NM_001267558 NP_001254487 NM_001267559 NP_001254488 NM_013232 NP_037364 NR_073609
|
| Function |
Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Seems to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca(2+) affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5. {ECO:0000250, ECO:0000269|PubMed:16132846, ECO:0000269|PubMed:17889823, ECO:0000269|PubMed:19520058, ECO:0000269|PubMed:19864416, ECO:0000269|PubMed:21893193}.
|
| Subcellular Location |
Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Endosome. Note=Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus. Translocated from the cytoplasm to the nucleus after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules.
|
![Western Blot: PDCD6 Overexpression Lysate (Adult Normal) [NBL1-14209] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PDCD6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/19473_PDCD6%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-14209-img0002.jpg)