PDCD6

Gene Symbol	PDCD6
Entrez Gene	10016
Alt Symbol	ALG-2, ALG2, PEF1B
Species	Human
Gene Type	protein-coding
Description	programmed cell death 6
Other Description	apoptosis-linked gene 2 protein|probable calcium-binding protein ALG-2|programmed cell death protein 6
Swissprots	O75340 B2RD16 E7ESR3 Q5TZS0 Q2YDC2
Accessions	EAW50987 EAW50990 EAW50991 O75340 AF035606 AAC27697 AK001917 AK024175 AK124302 AK128087 BAC87267 AK223366 BAD97086 AK295082 BAG58124 AK308872 AK310347 AK315370 BAG37763 AW300963 BC012384 AAH12384 BC028242 BC050597 AAH50597 BC106706 AAI06707 BC110291 AAI10292 BG390506 BI553617 BT020072 AAV38875 CR983268 DB495449 DQ891163 ABM82089 DQ894344 ABM85270 U58773 AAF14336 NM_001267556 NP_001254485 NM_001267557 NP_001254486 NM_001267558 NP_001254487 NM_001267559 NP_001254488 NM_013232 NP_037364 NR_073609
Function	Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Seems to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca(2+) affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5. {ECO:0000250, ECO:0000269|PubMed:16132846, ECO:0000269|PubMed:17889823, ECO:0000269|PubMed:19520058, ECO:0000269|PubMed:19864416, ECO:0000269|PubMed:21893193}.
Subcellular Location	Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Endosome. Note=Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus. Translocated from the cytoplasm to the nucleus after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PDCD6 full length protein - ab104605 from Abcam Category Protein Source E. coli Species Human

Recombinant Human PDCD6 Protein - H00010016-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PDCD6 Partial Recombinant Protein - H00010016-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PDCD6 Protein - NBP1-51048 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E. coli Species Human

Human ALG2 protein - orb245218 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human PDCD6 protein - orb168999 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E. coli

PDCD6 protein (His tag) - 80R-1736 from Fitzgerald Category Protein Prices $340.00 Sizes 50 µg Source E.coli

PDCD6 (1-191, His-tag) - AR09918PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

PDCD6 (1-191, His-tag) - AR09918PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

PDCD6 - H00010016-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PDCD6 - H00010016-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PDCD6 - H00010016-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PDCD6 - H00010016-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Programmed Cell Death 6, Human Recombinant - 228-12938-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Programmed Cell Death 6 - 228-12938-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Programmed Cell Death 6 - 228-12938-3 from RayBiotech Category Protein Source Escherichia Coli. Species Human

PDCD6, 1-191aa, Human, His tag, E.coli - 01-P0978 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

PDCD6 fusion protein - Ag2949 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

PDCD6 Human - PRPS-191 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human Programmed Cell Death 6 Protein - BP002400-PRO-184 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

PDCD6, 1-191aa, Recombinant Protein - GWB-P1060G from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 50 μg, 250 μg Source E.coli Species Human

PDCD6 Human Protein - GWB-BSP569 from Genway Biotech Category Protein Prices $75.00, $165.00, $6,190.00 Sizes 2 μg, 10 μg, 1000 μg Source Escherichia Coli. Species Human

Recombinant Human PDCD6, His-tagged - PDCD6-3427H from Creative Biomart Category Protein

Recombinant Human PDCD6, His-tagged - PDCD6-30798TH from Creative Biomart Category Protein Source E. coli

Recombinant Human PDCD6, GST-tagged - PDCD6-1595H from Creative Biomart Category Protein Source E.coli Species Human

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