PDCD6

Gene Symbol	PDCD6
Entrez Gene	10016
Alt Symbol	ALG-2, ALG2, PEF1B
Species	Human
Gene Type	protein-coding
Description	programmed cell death 6
Other Description	apoptosis-linked gene 2 protein|probable calcium-binding protein ALG-2|programmed cell death protein 6
Swissprots	O75340 B2RD16 E7ESR3 Q5TZS0 Q2YDC2
Accessions	EAW50987 EAW50990 EAW50991 O75340 AF035606 AAC27697 AK001917 AK024175 AK124302 AK128087 BAC87267 AK223366 BAD97086 AK295082 BAG58124 AK308872 AK310347 AK315370 BAG37763 AW300963 BC012384 AAH12384 BC028242 BC050597 AAH50597 BC106706 AAI06707 BC110291 AAI10292 BG390506 BI553617 BT020072 AAV38875 CR983268 DB495449 DQ891163 ABM82089 DQ894344 ABM85270 U58773 AAF14336 NM_001267556 NP_001254485 NM_001267557 NP_001254486 NM_001267558 NP_001254487 NM_001267559 NP_001254488 NM_013232 NP_037364 NR_073609
Function	Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Seems to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca(2+) affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5. {ECO:0000250, ECO:0000269|PubMed:16132846, ECO:0000269|PubMed:17889823, ECO:0000269|PubMed:19520058, ECO:0000269|PubMed:19864416, ECO:0000269|PubMed:21893193}.
Subcellular Location	Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Endosome. Note=Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus. Translocated from the cytoplasm to the nucleus after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PDCD6 - MBS1278086 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC028242

PDCD6 - MBS1273013 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC106706

PDCD6 - MBS1270493 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC012384

Human PDCD6 Gene ORF cDNA clone in cloning vector - HG11589-G from Sino Biological Species Human

Human PDCD6 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11589-NF from Sino Biological Species Human

Human PDCD6 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11589-ACR from Sino Biological Species Human

Human PDCD6 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11589-ANG from Sino Biological Species Human

Human PDCD6 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11589-ANR from Sino Biological Species Human

Human PDCD6 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11589-CF from Sino Biological Species Human

Human PDCD6 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11589-NM from Sino Biological Species Human

Human PDCD6 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11589-CM from Sino Biological Species Human

Human PDCD6 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11589-ACG from Sino Biological Species Human

Human PDCD6 Gene ORF cDNA clone expression plasmid - HG11589-UT from Sino Biological Species Human

Human PDCD6 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11589-NY from Sino Biological Species Human

Human PDCD6 Gene ORF cDNA clone expression plasmid, N-His tag - HG11589-NH from Sino Biological Species Human

Human PDCD6 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11589-CY from Sino Biological Species Human

Human PDCD6 Gene ORF cDNA clone expression plasmid, C-His tag - HG11589-CH from Sino Biological Species Human

Human PDCD6 ORF clone(NM_013232.3) - CDCL185651 from Creative biogene Species Human

Mouse PDCD6 ORF clone (NM_001267556.1) - CDCL147233 from Creative biogene Species Human

Human PDCD6 ORF clone (NM_001267557.1) - CDCL147235 from Creative biogene Species Human

Mouse PDCD6 ORF clone (NM_001267558.1) - CDCL147237 from Creative biogene Species Human

Human PDCD6 ORF clone (NM_001267559.1) - CDCL147239 from Creative biogene Species Human

Human PDCD6 ORF Clone (BC028242) - CDCS413360 from Creative biogene Species Human Accession O75340

Human PDCD6 ORF Clone (BC012384) - CDCS413361 from Creative biogene Species Human Accession O75340

Human PDCD6 ORF Clone (BC106706) - CDCS413362 from Creative biogene Species Human Accession O75340

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