| Gene Symbol | AGAP2 |
|---|---|
| Entrez Gene | 116986 |
| Alt Symbol | CENTG1, GGAP2, PIKE |
| Species | Human |
| Gene Type | protein-coding |
| Description | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 |
| Other Description | Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2|GTP-binding and GTPase activating protein 2|arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2|centaurin, gamma 1|cnt-g1|phosphatidylinositol 3-kinase enhancer|phosphatidylinositol-3-kinase enhancer|phosphoinositide 3-kinase enhancer |
| Swissprots | Q8IWU3 Q99490 A8K9F7 Q548E0 O00578 |
| Accessions | AAC39522 EAW97048 EAW97049 EAW97050 EAW97051 Q99490 AF384128 AAO39848 AF413077 AAL04171 AK122827 BAG53747 AK292672 BAF85361 AV740795 AY128689 AAM97540 BC028020 AAH28020 BE280072 BI755875 D79989 BAA11484 DB165417 XM_005268625 XP_005268682 XM_005268626 XP_005268683 XR_245891 NM_001122772 NP_001116244 NM_014770 NP_055585 |
| Function | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}. |
| Subcellular Location | Isoform 1: Cytoplasm. Nucleus. |
| Tissue Specificity | Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295, ECO:0000269|PubMed:16150119}. |
| Top Pathways | Endocytosis |
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP2), Human, ELISA Kit - E01A1312 from ARP American Research Products
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Arf GAP with GTPase, ANK repeat and PH domain containing protein 2 (AGAP2), ELISA Kit - MBS7200291 from MyBioSource
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Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP2), ELISA Kit - MBS7249975 from MyBioSource
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Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP2), ELISA Kit - MBS7206732 from MyBioSource
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Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP2), ELISA Kit - MBS7252313 from MyBioSource
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Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP2), ELISA Kit - MBS7221613 from MyBioSource
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Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP2), ELISA Kit - MBS7226238 from MyBioSource
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Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP2), ELISA Kit - MBS7203459 from MyBioSource
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Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP2), ELISA Kit - MBS7209124 from MyBioSource
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Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP2), ELISA Kit - MBS7235793 from MyBioSource
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Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP2), ELISA Kit - MBS7221467 from MyBioSource
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Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP2), ELISA Kit - MBS7234276 from MyBioSource
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Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP2), ELISA Kit - MBS7201273 from MyBioSource
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ArfGAP with GTPase domain, ankyrin repeat and PH domain 2, ELISA Kit - MBS9323692 from MyBioSource
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Centaurin Gamma 1 (CENTg1), ELISA Kit - MBS9312147 from MyBioSource
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Human AGAP2 ELISA Kit - E003564 from Biobool
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Human CENTg1 ELISA Kit - E007743 from Biobool
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anti-CENTG1 / PIKE antibody - ARG64931 from Arigo Biolaboratories
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