AGAP2

Gene Symbol	AGAP2
Entrez Gene	116986
Alt Symbol	CENTG1, GGAP2, PIKE
Species	Human
Gene Type	protein-coding
Description	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Other Description	Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2|GTP-binding and GTPase activating protein 2|arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2|centaurin, gamma 1|cnt-g1|phosphatidylinositol 3-kinase enhancer|phosphatidylinositol-3-kinase enhancer|phosphoinositide 3-kinase enhancer
Swissprots	Q8IWU3 Q99490 A8K9F7 Q548E0 O00578
Accessions	AAC39522 EAW97048 EAW97049 EAW97050 EAW97051 Q99490 AF384128 AAO39848 AF413077 AAL04171 AK122827 BAG53747 AK292672 BAF85361 AV740795 AY128689 AAM97540 BC028020 AAH28020 BE280072 BI755875 D79989 BAA11484 DB165417 XM_005268625 XP_005268682 XM_005268626 XP_005268683 XR_245891 NM_001122772 NP_001116244 NM_014770 NP_055585
Function	GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}.
Subcellular Location	Isoform 1: Cytoplasm. Nucleus.
Tissue Specificity	Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295, ECO:0000269|PubMed:16150119}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human Centaurin gamma 1 full length protein - ab132227 from Abcam Category Protein Source Wheat germ Species Human

Human Centaurin gamma 1 peptide - ab39846 from Abcam Category Peptide Species Human

AGAP2 / PIKE Antibody Blocking Peptide - LS-E614 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AGAP2 / PIKE Antibody Blocking Peptide - LS-E18826 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AGAP2 / PIKE Antibody Blocking Peptide - LS-E30070 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

AGAP2 / PIKE Antibody Blocking Peptide - LS-E27049 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human AGAP2 Protein - H00116986-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

AGAP2 Blocking Peptide - NBP1-77194PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

CENTG1-Antibody-C-term-Blocking-peptide - BP10947b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CENTG1 blocking peptide - GTX88422-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

CENTG1 Blocking Peptide - 33R-1240 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Centaurin gamma 1 Peptide - AC21-1871-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

AGAP2 / CENTG1 - H00116986-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

AGAP2 / CENTG1 - H00116986-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

AGAP2 / CENTG1 Control Peptide - AP30672CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

PIKE Peptide - 3321P from ProSci Category Peptide Species Human

PIKE Peptide - 46-997P from ProSci Category Peptide Species Human

AGAP2 fusion protein - ag6142 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human Arf-GAP with GTPase, ANK repeat and PH domain-containing prote - CSB-YP858713HU CSB-EP858713HU CSB-BP858713HU CSB-MP858713HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2(AGAP2) ,partial, Recombinant Protein - MBS1391380 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

CENTG1/PIKE, Peptide - MBS425660 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

AGAP2 Recombinant Protein Antigen - NBP1-85686PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

AGAP2 Peptide, Human - M34GP00360H from Creative Peptides Category Peptide Source Synthetic. Species Human

AGAP2 Immunizing peptide - orb16024 from Biorbyt Category Peptide

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