AGAP2

Gene Symbol AGAP2
Entrez Gene 116986
Alt Symbol CENTG1, GGAP2, PIKE
Species Human
Gene Type protein-coding
Description ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Other Description Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2|GTP-binding and GTPase activating protein 2|arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2|centaurin, gamma 1|cnt-g1|phosphatidylinositol 3-kinase enhancer|phosphatidylinositol-3-kinase enhancer|phosphoinositide 3-kinase enhancer
Swissprots Q8IWU3 Q99490 A8K9F7 Q548E0 O00578
Accessions AAC39522 EAW97048 EAW97049 EAW97050 EAW97051 Q99490 AF384128 AAO39848 AF413077 AAL04171 AK122827 BAG53747 AK292672 BAF85361 AV740795 AY128689 AAM97540 BC028020 AAH28020 BE280072 BI755875 D79989 BAA11484 DB165417 XM_005268625 XP_005268682 XM_005268626 XP_005268683 XR_245891 NM_001122772 NP_001116244 NM_014770 NP_055585
Function GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}.
Subcellular Location Isoform 1: Cytoplasm. Nucleus.
Tissue Specificity Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295, ECO:0000269|PubMed:16150119}.
Top Pathways Endocytosis

PIKE (h): 293T Lysate - sc-114780 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

Panoply™ Human AGAP2 Knockdown Stable Cell Line - CSC-DC000360 from Creative biogene

Category Cell Line
Species Human
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