| Gene Symbol |
AGAP2
|
| Entrez Gene |
116986
|
| Alt Symbol |
CENTG1, GGAP2, PIKE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
|
| Other Description |
Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2|GTP-binding and GTPase activating protein 2|arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2|centaurin, gamma 1|cnt-g1|phosphatidylinositol 3-kinase enhancer|phosphatidylinositol-3-kinase enhancer|phosphoinositide 3-kinase enhancer
|
| Swissprots |
Q8IWU3 Q99490 A8K9F7 Q548E0 O00578
|
| Accessions |
AAC39522 EAW97048 EAW97049 EAW97050 EAW97051 Q99490 AF384128 AAO39848 AF413077 AAL04171 AK122827 BAG53747 AK292672 BAF85361 AV740795 AY128689 AAM97540 BC028020 AAH28020 BE280072 BI755875 D79989 BAA11484 DB165417 XM_005268625 XP_005268682 XM_005268626 XP_005268683 XR_245891 NM_001122772 NP_001116244 NM_014770 NP_055585
|
| Function |
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}.
|
| Subcellular Location |
Isoform 1: Cytoplasm. Nucleus.
|
| Tissue Specificity |
Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295, ECO:0000269|PubMed:16150119}.
|
| Top Pathways |
Endocytosis
|