PIAS3

Gene Symbol	PIAS3
Entrez Gene	10401
Alt Symbol	ZMIZ5
Species	Human
Gene Type	protein-coding
Description	protein inhibitor of activated STAT, 3
Other Description	E3 SUMO-protein ligase PIAS3|protein inhibitor of activated STAT protein 3|zinc finger, MIZ-type containing 5
Swissprots	Q9UFI3 Q9Y6X2
Accessions	EAW71429 EAW71430 EAW71431 Q9Y6X2 AB021868 BAA78533 AK027557 BAG51345 AK125158 AK294231 BAG57533 AK304039 BAG64950 AL122061 CAB59241 AL133016 CAB61357 BC001154 AAH01154 BC030556 AAH30556 BE247489 BT007036 AAP35684 CR457090 CAG33371 DQ893542 ABM84468 DQ893796 ABM84722 DQ895037 ABM85963 EU176644 ABW03445 NM_006099 NP_006090
Function	Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. {ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:9388184}.
Subcellular Location	Cytoplasm. Nucleus. Note=Mainly cytoplasmic but shuttles between the nucleus and cytoplasm. Transported to the nucleus on interaction with phosphorylated STAT3. Colocalizes with GFI1 in nuclear dots (By similarity). {ECO:0000250}.
Tissue Specificity	Isoform 1 is expressed in most tissues except thymus and small intestine. Isoform 3 is expressed only in brain, heart, thymus, muscle, lung, testis, lactating breast and embryonic stem cells. {ECO:0000269|PubMed:9388184}.
Top Pathways	Ubiquitin mediated proteolysis, Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat PIAS3 ELISA Kit (Cell-Based ELISA) - LS-F2243 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Human PIAS3 ELISA Kit (Sandwich ELISA) - LS-F9857 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.061 ng/ml Range 0.156-10 ng/ml

Human PIAS3 ELISA Kit - abx152733 from Abbexa Category ELISA Kit Sensitivity 0.064 ng/ml Range 0.156 ng/ml - 10 ng/ml

E3 SUMO-protein ligase PIAS3, PIAS3, Human, ELISA Kit - E1591h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Protein Inhibitor of Activated STAT3, PIAS3, Human, ELISA Kit - E-EL-H0937 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Protein Inhibitor of Activated STAT3, PIAS3, Rabbit, ELISA Kit - E-EL-RB1209 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protein Inhibitor of Activated STAT3, PIAS3, Chicken, ELISA Kit - E-EL-Ch1658 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Protein Inhibitor of Activated STAT3, PIAS3, Porcine, ELISA Kit - E-EL-P2234 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protein Inhibitor of Activated STAT3, PIAS3, Monkey, ELISA Kit - E-EL-MK0055 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protein Inhibitor Of Activated STAT 3 (PIAS3), ELISA Kit - MBS2020543 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.064ng/mL. Range 0.156-10ng/mL

Protein inhibitor of activated STAT3 (PIAS3), ELISA Kit - MBS260145 from MyBioSource Category ELISA Kit Prices $290.00, $450.00, $1,755.00, $3,150.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein inhibitor of activated STAT3 (PIAS3), ELISA Kit - MBS268100 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein inhibitor of activated STAT3 (PIAS3), ELISA Kit - MBS266578 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein inhibitor of activated STAT3 (PIAS3), ELISA Kit - MBS2602112 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein inhibitor of activated STAT3 (PIAS3) - MBS260484 from MyBioSource Category ELISA Kit Prices $315.00, $490.00 Sizes 48 strip wells, 96 strip wells

Protein inhibitor of activated STAT3 (PIAS3), ELISA Kit - MBS263574 from MyBioSource Category ELISA Kit Prices $290.00, $450.00, $1,755.00, $3,150.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein inhibitor of activated STAT3 (PIAS3), ELISA Kit - MBS263601 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein inhibitor of activated STAT3 (PIAS3), ELISA Kit - MBS266942 from MyBioSource Category ELISA Kit Prices $275.00, $420.00, $1,615.00, $2,880.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein inhibitor of activated STAT3, PIAS3, ELISA Kit - MBS9301113 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

PIAS3 Colorimetric Cell-Based ELISA Kit - CB5556 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human PIAS3(Protein Inhibitor of Activated STAT3) ELISA Kit - E-EL-H0937 from Elabscience Category ELISA Kit Sensitivity 37.50 pg/mL Range 62.50—4000 pg/mL

PIAS3, ELISA Kit - MBS2506330 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

PIAS3, ELISA Kit - MBS2514800 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

PIAS3, ELISA Kit - MBS2501018 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.5pg/mL Range 2.5-160pg/mL

PIAS3, ELISA Kit - MBS2505919 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

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