| Gene Symbol |
PIAS3
|
| Entrez Gene |
10401
|
| Alt Symbol |
ZMIZ5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein inhibitor of activated STAT, 3
|
| Other Description |
E3 SUMO-protein ligase PIAS3|protein inhibitor of activated STAT protein 3|zinc finger, MIZ-type containing 5
|
| Swissprots |
Q9UFI3 Q9Y6X2
|
| Accessions |
EAW71429 EAW71430 EAW71431 Q9Y6X2 AB021868 BAA78533 AK027557 BAG51345 AK125158 AK294231 BAG57533 AK304039 BAG64950 AL122061 CAB59241 AL133016 CAB61357 BC001154 AAH01154 BC030556 AAH30556 BE247489 BT007036 AAP35684 CR457090 CAG33371 DQ893542 ABM84468 DQ893796 ABM84722 DQ895037 ABM85963 EU176644 ABW03445 NM_006099 NP_006090
|
| Function |
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. {ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:9388184}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Mainly cytoplasmic but shuttles between the nucleus and cytoplasm. Transported to the nucleus on interaction with phosphorylated STAT3. Colocalizes with GFI1 in nuclear dots (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Isoform 1 is expressed in most tissues except thymus and small intestine. Isoform 3 is expressed only in brain, heart, thymus, muscle, lung, testis, lactating breast and embryonic stem cells. {ECO:0000269|PubMed:9388184}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Jak-STAT signaling pathway
|