PIAS3

Gene Symbol	PIAS3
Entrez Gene	10401
Alt Symbol	ZMIZ5
Species	Human
Gene Type	protein-coding
Description	protein inhibitor of activated STAT, 3
Other Description	E3 SUMO-protein ligase PIAS3|protein inhibitor of activated STAT protein 3|zinc finger, MIZ-type containing 5
Swissprots	Q9UFI3 Q9Y6X2
Accessions	EAW71429 EAW71430 EAW71431 Q9Y6X2 AB021868 BAA78533 AK027557 BAG51345 AK125158 AK294231 BAG57533 AK304039 BAG64950 AL122061 CAB59241 AL133016 CAB61357 BC001154 AAH01154 BC030556 AAH30556 BE247489 BT007036 AAP35684 CR457090 CAG33371 DQ893542 ABM84468 DQ893796 ABM84722 DQ895037 ABM85963 EU176644 ABW03445 NM_006099 NP_006090
Function	Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. {ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:9388184}.
Subcellular Location	Cytoplasm. Nucleus. Note=Mainly cytoplasmic but shuttles between the nucleus and cytoplasm. Transported to the nucleus on interaction with phosphorylated STAT3. Colocalizes with GFI1 in nuclear dots (By similarity). {ECO:0000250}.
Tissue Specificity	Isoform 1 is expressed in most tissues except thymus and small intestine. Isoform 3 is expressed only in brain, heart, thymus, muscle, lung, testis, lactating breast and embryonic stem cells. {ECO:0000269|PubMed:9388184}.
Top Pathways	Ubiquitin mediated proteolysis, Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PIAS3 protein fragment - ab125996 from Abcam Category Protein Source E. coli Species Human

PIAS3 Antibody Blocking Peptide - LS-E30923 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PIAS3 Antibody Blocking Peptide - LS-E11526 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIAS3 Antibody Blocking Peptide - LS-E11527 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PIAS3 Protein - H00010401-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PIAS3 Protein - H00010401-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

PIAS3 Blocking Peptide - NBP1-77160PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

PIAS3 Peptide - P0310 from Novus Biologicals Category Peptide Species Human

PIAS3 Peptide - P0309 from Novus Biologicals Category Peptide Species Human

PIAS3-Antibody-N-term-Blocking-Peptide - BP1245a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIAS3-Antibody-C-term-Blocking-Peptide - BP1244a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIAS3 peptide - orb218338 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Dog

PIAS3 Blocking Peptide - abx063669 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Dog, Pig

PIAS3 - H00010401-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

PIAS3 - H00010401-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PIAS3 - H00010401-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PIAS3 Control Peptide - AP30667CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

PIAS3 Peptide - 5745P from ProSci Category Peptide Species Human

PIAS3 fusion protein - Ag4304 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

PIAS3 fusion protein - Ag5774 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human PIAS3, GST-tagged - PIAS3-1704H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Protein Inhibitor Of Activated STAT 3 (PIAS3) - RPE590Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

PIAS3 Blocking Peptide - CBP2475 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Dog, Pig

PIAS 3 (F25) Peptide - BS1467P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Protein Inhibitor Of Activated STAT 3 (PIAS3) - RPE590Hu01 from Cloud-clone Category Protein Source E.coli Species Human

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