| Gene Symbol |
GRIK1
|
| Entrez Gene |
2897
|
| Alt Symbol |
EAA3, EEA3, GLR5, GLUR5, GluK1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glutamate receptor, ionotropic, kainate 1
|
| Other Description |
excitatory amino acid receptor 3|gluR-5|glutamate receptor 5|glutamate receptor ionotropic, kainate 1
|
| Swissprots |
Q13001 Q86SU9 P39086
|
| Accessions |
AAD03059 AAD04931 BAA97452 EAX09906 EAX09907 EAX09908 EAX09909 EAX09910 P39086 AA404271 AJ249208 CAC80546 AK294353 BAH11742 AK296404 BAH12343 BC028238 BC039447 BC111793 BC152727 AAI52728 BC156975 AAI56976 L19058 AAA52568 U16125 AAA95961 XM_005260942 XP_005260999 XM_005260943 XP_005261000 XM_005260944 XP_005261001 XM_006723991 XP_006724054 XM_011529527 XP_011527829 XM_011529528 XP_011527830 NM_000830 NP_000821 NM_175611 NP_783300
|
| Function |
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.
|
| Top Pathways |
Glutamatergic synapse, Neuroactive ligand-receptor interaction
|