GRIK1
| Gene Symbol | GRIK1 |
|---|---|
| Entrez Gene | 2897 |
| Alt Symbol | EAA3, EEA3, GLR5, GLUR5, GluK1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutamate receptor, ionotropic, kainate 1 |
| Other Description | excitatory amino acid receptor 3|gluR-5|glutamate receptor 5|glutamate receptor ionotropic, kainate 1 |
| Swissprots | Q13001 Q86SU9 P39086 |
| Accessions | AAD03059 AAD04931 BAA97452 EAX09906 EAX09907 EAX09908 EAX09909 EAX09910 P39086 AA404271 AJ249208 CAC80546 AK294353 BAH11742 AK296404 BAH12343 BC028238 BC039447 BC111793 BC152727 AAI52728 BC156975 AAI56976 L19058 AAA52568 U16125 AAA95961 XM_005260942 XP_005260999 XM_005260943 XP_005261000 XM_005260944 XP_005261001 XM_006723991 XP_006724054 XM_011529527 XP_011527829 XM_011529528 XP_011527830 NM_000830 NP_000821 NM_175611 NP_783300 |
| Function | Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus. |
| Top Pathways | Glutamatergic synapse, Neuroactive ligand-receptor interaction |
GluR-5 CRISPR/Cas9 KO Plasmid (h) - sc-402475 from Santa Cruz Biotechnology
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GluR-5 HDR Plasmid (h) - sc-402475-HDR from Santa Cruz Biotechnology
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GluR-5 Double Nickase Plasmid (h) - sc-402475-NIC from Santa Cruz Biotechnology
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GluR-5 Double Nickase Plasmid (h2) - sc-402475-NIC-2 from Santa Cruz Biotechnology
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GluR-5 CRISPR Activation Plasmid (h) - sc-402475-ACT from Santa Cruz Biotechnology
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GluR-5 CRISPR Activation Plasmid (h2) - sc-402475-ACT-2 from Santa Cruz Biotechnology
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GluR-5 Lentiviral Activation Particles (h) - sc-402475-LAC from Santa Cruz Biotechnology
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GluR-5 Lentiviral Activation Particles (h2) - sc-402475-LAC-2 from Santa Cruz Biotechnology
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GluR-5 siRNA (h) - sc-42487 from Santa Cruz Biotechnology
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GluR-5 shRNA Plasmid (h) - sc-42487-SH from Santa Cruz Biotechnology
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GluR-5 shRNA (h) Lentiviral Particles - sc-42487-V from Santa Cruz Biotechnology
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GluR5/GRIK1 RNAi - H00002897-R01 from Novus Biologicals
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GluR5/GRIK1 RNAi - H00002897-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN9680 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9680 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01694 from Sigma-Aldrich
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GRIK1 siRNA (Human) - CRH1951 from Cohesion Biosciences
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GRIK1 - MBS8236592 from MyBioSource
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shRNA set against Human GRIK1 (NM_000830.3) - SHH307826 from Creative biogene
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shRNA set against Human GRIK1(NM_000830.3) - SHH104267 from Creative biogene
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shRNA set against Human GRIK1(NM_175611.2) - SHH104339 from Creative biogene
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Human GRIK1 siRNA - orb262453 from Biorbyt
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GRIK1 shRNA Plasmid (Human) - CHH1951 from Cohesion Biosciences
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GRIK1 miRNA 3'UTR clone - MiUTR1H-04269 from Creative biogene
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GRIK1 miRNA 3'UTR clone - MiUTR3H-00884 from Creative biogene
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