| Gene Symbol |
ZFYVE19
|
| Entrez Gene |
84936
|
| Alt Symbol |
ANCHR, MPFYVE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger, FYVE domain containing 19
|
| Other Description |
MLL partner containing FYVE domain|abscission/NoCut checkpoint regulator|zinc finger FYVE domain-containing protein 19
|
| Swissprots |
Q8WU96 Q86WC2 H3BUF9 Q96K21 B3KVB2 C9JNF4
|
| Accessions |
EAW92447 EAW92448 EAW92449 EAW92450 EAW92451 EAW92452 EAW92453 EAW92454 EAW92455 Q96K21 AB209224 BAD92461 AF445414 AAO73862 AK027746 BAB55338 AK122779 BAG53724 AK225553 BC015738 BC021092 AAH21092 BI860679 DA611931 DA653225 DB012963 DQ575146 XR_931925 NM_001077268 NP_001070736 NM_001258420 NP_001245349 NM_001258421 NP_001245350 NM_032850 NP_116239
|
| Function |
Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. {ECO:0000269|PubMed:24814515}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24814515}. Cleavage furrow {ECO:0000269|PubMed:24814515}. Midbody {ECO:0000269|PubMed:24814515}. Note=Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis (PubMed:24814515). {ECO:0000269|PubMed:24814515}.
|
| Tissue Specificity |
Detected in brain, heart, skeletal muscle, kidney and liver. {ECO:0000269|PubMed:12618766}.
|