ZFYVE19
| Gene Symbol | ZFYVE19 |
|---|---|
| Entrez Gene | 84936 |
| Alt Symbol | ANCHR, MPFYVE |
| Species | Human |
| Gene Type | protein-coding |
| Description | zinc finger, FYVE domain containing 19 |
| Other Description | MLL partner containing FYVE domain|abscission/NoCut checkpoint regulator|zinc finger FYVE domain-containing protein 19 |
| Swissprots | Q8WU96 Q86WC2 H3BUF9 Q96K21 B3KVB2 C9JNF4 |
| Accessions | EAW92447 EAW92448 EAW92449 EAW92450 EAW92451 EAW92452 EAW92453 EAW92454 EAW92455 Q96K21 AB209224 BAD92461 AF445414 AAO73862 AK027746 BAB55338 AK122779 BAG53724 AK225553 BC015738 BC021092 AAH21092 BI860679 DA611931 DA653225 DB012963 DQ575146 XR_931925 NM_001077268 NP_001070736 NM_001258420 NP_001245349 NM_001258421 NP_001245350 NM_032850 NP_116239 |
| Function | Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. {ECO:0000269|PubMed:24814515}. |
| Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24814515}. Cleavage furrow {ECO:0000269|PubMed:24814515}. Midbody {ECO:0000269|PubMed:24814515}. Note=Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis (PubMed:24814515). {ECO:0000269|PubMed:24814515}. |
| Tissue Specificity | Detected in brain, heart, skeletal muscle, kidney and liver. {ECO:0000269|PubMed:12618766}. |
ZFYVE19 CRISPR/Cas9 KO Plasmid (h) - sc-413741 from Santa Cruz Biotechnology
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ZFYVE19 HDR Plasmid (h) - sc-413741-HDR from Santa Cruz Biotechnology
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ZFYVE19 Double Nickase Plasmid (h) - sc-413741-NIC from Santa Cruz Biotechnology
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ZFYVE19 Double Nickase Plasmid (h2) - sc-413741-NIC-2 from Santa Cruz Biotechnology
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ZFYVE19 CRISPR Activation Plasmid (h) - sc-413741-ACT from Santa Cruz Biotechnology
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ZFYVE19 CRISPR Activation Plasmid (h2) - sc-413741-ACT-2 from Santa Cruz Biotechnology
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ZFYVE19 Lentiviral Activation Particles (h) - sc-413741-LAC from Santa Cruz Biotechnology
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ZFYVE19 Lentiviral Activation Particles (h2) - sc-413741-LAC-2 from Santa Cruz Biotechnology
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ZFYVE19 siRNA (h) - sc-90097 from Santa Cruz Biotechnology
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ZFYVE19 shRNA Plasmid (h) - sc-90097-SH from Santa Cruz Biotechnology
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ZFYVE19 shRNA (h) Lentiviral Particles - sc-90097-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU134821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN23204 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23204 from Sigma-Aldrich
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ZFYVE19 siRNA (Human) - CRJ3707 from Cohesion Biosciences
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ZFYVE19 RNAi - H00084936-R01 from Novus Biologicals
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ZFYVE19 - MBS8220004 from MyBioSource
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shRNA set against Human ZFYVE19 (NM_001077268.1) - SHH452468 from Creative biogene
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Human ZFYVE19 siRNA - orb274208 from Biorbyt
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ZFYVE19 shRNA Plasmid (Human) - CHJ3707 from Cohesion Biosciences
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ZFYVE19 miRNA 3'UTR clone - MiUTR1H-11444 from Creative biogene
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ZFYVE19 miRNA 3'UTR clone - MiUTR4H-TG10071 from Creative biogene
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